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Overview

  • Product nameADAM21 protein (Tagged)See all ADAM21 proteins and peptides ...
  • Protein descriptionRecombinant full length Human ADAM21 (amino acids 1-722) with N terminal proprietary tag; Predicted MWt 107.2 kDa (inclusive of tag).
  • Uniprot accessionQ9UKJ8
  • Molecular weight107.200kDa inclusive of tags
  • Protein length722 amino acids
  • Expression hostWheat germ

    • Properties

  • E.C. Number3.4.24.-
  • FormLiquid
  • Storage instructionsShipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
  • Storage bufferpH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl
  • Concentration information loading...
  • Additional notesProtein concentration is above or equal to 0.05 ug/ul.
  • Sequence notesMAVDGTLVYIRVTLLLLWLGVFLSISGYCQAGPSQHFTSP EVVIPLKVISRGRSAKAPGWLSYSLRFGGQKHVVHMRVKK LLVSRHLPVFTYTDERALLEDQLFIPDDCYYHGYVEGAPE SLVVFSACFGGFRGVLKISGLTYEIEPIRHSATFEHLVYK VNSNETQFPAMRCGLTEKEVARQQLEFEEAENSALEPKSA GDWWTHAWFLELVVVVNHDFFIYSQSNISKVQEDVFLVVN IVDSMYQQLGTYIILIGIEIWNQGNVFPMTSIEQVLNDFS QWKQISLSQLQHDAAHMFIKNSLISILGLAYVAGICRPPI DCGVDNFQGDTWSLFANTVAHELGHTLGMQHDEEFCFCGE RGCIMNTFRVPAEKFTNCSYADFMKTTLNQGSCLHNPPRL GEIFMLKRCGNGVVEREEQCDCGSVQQCEQDACCLLNCTL RPGAACAFGLCCKDCKFMPSGELCRQEVNECDLPEWCNGT SHQCPEDRYVQDGIPCSDSAYCYQKRCNNHDQHCREIFGK DAKSASQNCYKEINSQGNRFGHCGINGTTYLKCHISDVFC GRVQCENVRDIPLLQDHFTLQHTHINGVTCWGIDYHLRMN ISDIGEVKDGTVCGPGKICIHKKCVSLSVLSHVCLPETCN MKGICNNKHHCHCGYGWSPPYCQHRGYGGSIDSGPASAKR GVFLPLIVIPSLSVLTFLFTVGLLMYLRQCSGPKETKAHS SG
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab132360 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    WB WB: Use at an assay dependent concentration.
    SDS-PAGE SDS-PAGE: Use at an assay dependent concentration.
    ELISA ELISA: Use at an assay dependent concentration.
  • Application notesThis peptide can be used with studies using ab169625.

    • Protein info

    • Alternative names
        A disintegrin and metalloproteinase domain 21ADA21_HUMANADAM 21
        ADAM metallopeptidase domain 21ADAM metallopeptidase domain 21, preproproteinAdam21ADAM31Disintegrin and metalloproteinase domain-containing protein 21
      see all
  • FunctionMay be involved in sperm maturation and/or fertilization. May also be involved in epithelia functions associated with establishing and maintaining gradients of ions or nutrients.
  • Sequence similaritiesContains 1 disintegrin domain.
    Contains 1 EGF-like domain.
    Contains 1 peptidase M12B domain.
  • DomainA tripeptide motif (VGE) within disintegrin-like domain could be involved in the binding to egg integrin receptor and thus could mediate sperm/egg binding.
    The cysteine-rich domain encodes putative cell-fusion peptides, which could be involved in sperm-egg fusion.
    The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Post-translational
    modifications    Has no obvious cleavage site for furin endopeptidase, suggesting that the proteolytic processing is regulated.
  • Cellular localizationMembrane.

    • Target information above from: UniProt accession Q9UKJ8 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    ADAM21 protein (Tagged) images

    • SDS-PAGE - ADAM21 protein (Tagged) (ab132360)
      SDS-PAGE - ADAM21 protein (Tagged) (ab132360)
      12.5% SDS-PAGE analysis of ab132360 stained with Coomassie Blue.

    References for ADAM21 protein (Tagged) (ab132360)

    ab132360 has not yet been referenced specifically in any publications.

    Publishing research using ab132360 ? Please let us know so that we can cite the reference in this datasheet

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