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Products:Cell Biology >> Apoptosis >> Receptors >> Receptor Processing
Overview
Product name
Anti-ADAM8 antibody - Aminoterminal end
See all ADAM8 products (6) ...
Description
Rabbit polyclonal to ADAM8 - Aminoterminal end
Specificity
This antibody is specific for ADAM8. It does not react with the other ADAMs.
Tested applications
Cross reactivity
Reacts with
Rat, Human, Pig
Immunogen
Synthetic peptide based on the aminoterminal end of the catalytic domain of active human ADAM8.
Properties
Form
Liquid
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.01% Sodium Azide
Constituents: 50% Glycerol
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Purification notes
This antibody has been peptide-affinity purified.
Clonality
Polyclonal
Isotype
IgG
Research areas
Cell Biology >> Proteolysis / Ubiquitin >> Proteolytic enzymes >> Metalloprotease >> ADAMs
Cancer >> Invasion/microenvironment >> ECM >> Extracellular matrix >> ADAM protein family
Signal Transduction >> Cytoskeleton / ECM >> Extracellular Matrix >> ECM Enzymes >> ADAM Protein Family
Cell Biology >> Apoptosis >> Receptors >> Receptor Processing
Applications
Show applications key
Our Abpromise guarantee covers the use of ab39173 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application notes
WB: 1/1000 when using colorimetric substrates such as BCIP/NBT, and 1/5000 for chemiluminescent substrates. Detects bands of approximately 75kDa and 60kDa (predicted molecular weight: 88 kDa). EDTA/EGTA treatment of tissues or lysates is required to see latent zymogen. Dilution optimised using Chromogenic detection. Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Target
Relevance
Members of ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. The extracellular region of ADAM8 shows significant amino acid sequence homology to hemorrhagic snake venom proteins, including the metalloprotease and disintegrin domains. The expression of ADAM8 is upregulated by retinoic acid and vitamin D3. The function of ADAM8 is still poorly understood. ADAM8 has been shown to stimulate osteoclasts, and to be produced by bone marrow cultures stimulated by vitamin-D. ADAM8 is involved in protein processing at the cell surface and is also thought to act as a leukocyte differentiation marker.
Cellular localization
Integral to plasma membrane
Alternative names
- A Disintegrin And Metalloproteinase domain 8 antibody
- A Disintegrin And Metalloproteinase domain 8 antibody
- ADAM 8 antibody
see all
Database links
- Entrez Gene: 101 Human
- Entrez Gene: 499285 Rat
- Omim: 602267 Human
- SwissProt: P78325 Human
- Unigene: 86947 Human
Protocols
References for Anti-ADAM8 antibody - Aminoterminal end (ab39173)
ab39173 has not yet been referenced specifically in any publications.
Publishing research using ab39173? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"