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Products:Cell Biology >> Apoptosis >> Receptors >> Receptor Processing
Overview
Product name
Anti-ADAM8 antibody
See all ADAM8 products (6) ...
Description
Goat polyclonal to ADAM8
Tested applications
Cross reactivity
Reacts with
Human
Immunogen
Synthetic peptide: QRKQGAGAPTAP, corresponding to C terminal amino acids 813-824 of ADAM8.
C-QRKQGAGA PTAP
Positive control
Human Brain lysate.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.02% Sodium Azide
Constituents: 0.5% BSA, 0.5mg/ml Tris, pH 7.3
Concentration
Concentration information loading...
Purity
IgG fraction
Purification notes
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Clonality
Polyclonal
Isotype
IgG
Research areas
Cell Biology >> Proteolysis / Ubiquitin >> Proteolytic enzymes >> Metalloprotease >> ADAMs
Cancer >> Invasion/microenvironment >> ECM >> Extracellular matrix >> ADAM protein family
Signal Transduction >> Cytoskeleton / ECM >> Extracellular Matrix >> ECM Enzymes >> ADAM Protein Family
Cell Biology >> Apoptosis >> Receptors >> Receptor Processing
Applications
Show applications key
Our Abpromise guarantee covers the use of ab2475 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB
Application notes
Western Blot – Approx 90kDa band seen in Human Brain lysate. Recommended for use at 1.0-3.0ug/ml.
Target
Relevance
Members of ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. The extracellular region of ADAM8 shows significant amino acid sequence homology to hemorrhagic snake venom proteins, including the metalloprotease and disintegrin domains. The expression of ADAM8 is upregulated by retinoic acid and vitamin D3. The function of ADAM8 is still poorly understood. ADAM8 has been shown to stimulate osteoclasts, and to be produced by bone marrow cultures stimulated by vitamin-D. ADAM8 is involved in protein processing at the cell surface and is also thought to act as a leukocyte differentiation marker.
Cellular localization
Integral to plasma membrane
Alternative names
- A Disintegrin And Metalloproteinase domain 8 antibody
- ADAM 8 antibody
- ADAM 8 precursor antibody
see all
Database links
- Entrez Gene: 101 Human
- Omim: 602267 Human
- SwissProt: P78325 Human
- Unigene: 86947 Human
References for Anti-ADAM8 antibody (ab2475)
ab2475 has not yet been referenced specifically in any publications.
Publishing research using ab2475? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"