ADAM9 antibody (ab11532)

Product Name 

ADAM9 antibody

Product type 

Primary antibodies

Description 

Rabbit polyclonal to ADAM9

Immunogen 

A synthetic peptide corresponding to the propeptide domain of human ADAM9.

Reacts with 
(species key)

Hu

Specificity 

This antibody may be used for the detection and localization of human ADAM9 and does not react with other ADAMs.

Tested applications 
(see key)

WB

Abreviews 

Customer reviews (see key)

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Application notes 
(see key)

Recommended dilutions
WB: 1/1000 - 1/5000. Detects a band of approximately 84 kDa (predicted molecular weight: 90.5 kDa). Detects a band of approximately 84 kDa (processed) or 114 kDa (unprocessed) (predicted molecular weight: 90.5 kDa).
Recognizes bands at 116 kDa (minor), 66 kDa (major), and breakdown products at 55 kDa and 34 kDa in reduced immunoblots.

Higher antibody dilutions may be necessary for non-human samples. EDTA/EGTA treatment of tissues or lysates is required to see latent zymogen.

Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Cellular localization 

Isoform 1: Cell membrane; single-pass type I membrane protein.
Isoform 2: Secreted protein.

Research areas 

Cell Biology >> Proteolysis / Ubiquitin >> Proteolytic enzymes >> Metalloprotease >> ADAMs
Cancer >> Invasion/microenvironment >> ECM >> Extracellular matrix >> ADAM protein family
Signal Transduction >> Cytoskeleton / ECM >> Extracellular Matrix >> ECM Enzymes >> ADAM Protein Family
Signal Transduction >> Cytoskeleton / ECM >> Extracellular Matrix >> ECM Enzymes >> MMP

Relevance 

ADAM9 encodes disintegrin and metalloprotease (ADAM) domain 9, which is a member of the ADAM protein family. Members of this family are membrane- anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell- cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The member encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor.

Database links 

Raised in 

Rabbit

Clonality 

Polyclonal

Isotype 

IgG

Purity 

Immunogen affinity purified

Storage buffer 

Preservative: 0.05% Sodium Azide
Constituents: 50% Glycerol, PBS

Material safety datasheets (MSDS) for this product:
Glycerol MSDS
Sodium Azide MSDS

Form 

Liquid

Concentration 

1.000 mg/ml

Storage instructions 

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Notes 

For extended storage, the solution may be stored -20 °C.
Do not store below -22 °C.
If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use.

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