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Products:Signal Transduction >> Cytoskeleton / ECM >> Extracellular Matrix >> ECM Enzymes >> MMP
Overview
Product name
Anti-ADAM9 antibody
See all ADAM9 products (9) ...
Description
Rabbit polyclonal to ADAM9
Specificity
This antibody may be used for the detection and localization of human ADAM9 and does not react with other ADAMs.
Tested applications
Cross reactivity
Reacts with
Human
Immunogen
A synthetic peptide corresponding to the propeptide domain of human ADAM9.
General notes
For extended storage, the solution may be stored -20 °C.
Do not store below -22 °C.
If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
Preservative: 0.05% Sodium Azide
Constituents: 50% Glycerol, PBS
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Cell Biology >> Proteolysis / Ubiquitin >> Proteolytic enzymes >> Metalloprotease >> ADAMs
Cancer >> Invasion/microenvironment >> ECM >> Extracellular matrix >> ADAM protein family
Signal Transduction >> Cytoskeleton / ECM >> Extracellular Matrix >> ECM Enzymes >> ADAM Protein Family
Signal Transduction >> Cytoskeleton / ECM >> Extracellular Matrix >> ECM Enzymes >> MMP
Applications
Show applications key
Our Abpromise guarantee covers the use of ab11532 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB
Application notes
WB: 1/1000 - 1/5000. Detects a band of approximately 84 kDa (predicted molecular weight: 90.5 kDa). Detects a band of approximately 84 kDa (processed) or 114 kDa (unprocessed) (predicted molecular weight: 90.5 kDa).
Recognizes bands at 116 kDa (minor), 66 kDa (major), and breakdown products at 55 kDa and 34 kDa in reduced immunoblots.
Higher antibody dilutions may be necessary for non-human samples. EDTA/EGTA treatment of tissues or lysates is required to see latent zymogen.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Relevance
ADAM9 encodes disintegrin and metalloprotease (ADAM) domain 9, which is a member of the ADAM protein family. Members of this family are membrane- anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell- cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The member encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor.
Cellular localization
Isoform 1: Cell membrane; single-pass type I membrane protein. Isoform 2: Secreted protein.
Alternative names
- A disintegrin and metalloproteinase domain 9 antibody
- ADAM 9 antibody
- ADAM metallopeptidase domain 9 antibody
see all
Database links
- Entrez Gene: 8754 Human
- Omim: 602713 Human
- SwissProt: B7ZLN7 Human
- SwissProt: Q10718 Human
- SwissProt: Q13443 Human
- Unigene: 591852 Human
References for Anti-ADAM9 antibody (ab11532)
ab11532 has not yet been referenced specifically in any publications.
Publishing research using ab11532? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"