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Products:Signal Transduction >> Cytoskeleton / ECM >> Extracellular Matrix >> ECM Enzymes >> ADAM Protein Family
Overview
Product name
Anti-ADAMTS10 antibody - Catalytic domain
See all ADAMTS10 products (2) ...
Description
Rabbit polyclonal to ADAMTS10 - Catalytic domain
Specificity
We have a range of domain specific antibodies for this target. For a full list please see all ADAMTS10 antibodies.
Tested applications
Cross reactivity
Reacts with
Human
Immunogen
A synthetic peptide based on the catalytic domain of human ADAMTS10.
General notes
Immunizing peptide available on request – please contact a member of staff to ask for availability
Properties
Form
Liquid
Storage instructions
Store at -20°C. Stable for 12 months at -20°C
Storage buffer
Preservative: 0.05% Sodium Azide
Constituents: 50% Glycerol, PBS, 500mM Sodium chloride, pH 7.4
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Cell Biology >> Proteolysis / Ubiquitin >> Proteolytic enzymes >> Metalloprotease >> ADAM TS
Signal Transduction >> Cytoskeleton / ECM >> Extracellular Matrix >> ECM Enzymes >> ADAM Protein Family
Applications
Show applications key
Our Abpromise guarantee covers the use of ab59813 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use at an assay dependent dilution. Predicted molecular weight: 118 kDa.(A recommended starting concentration for Western blots is 1/1000 when using colorimetric substrates such as BCIP/NBT and 1/5000 for chemiluminescent substrates. )
Target
Relevance
ADAMTS10 is a member of the ADAMs family of proteinases with Thrombospondin motifs. The catalytic site of ADAMTS10 is typical of the metalloproteinase catalytic domains, with an HExxHxxxxxH sequence, perhaps giving these enzymes some shared specificity. ADAMTS10 is closest in homology to ADAMTS6, sharing 53% overall identity. Functional mutations in ADAMTS10 have been linked to Weill Marchesani syndrome, a connective tissue disorder marked by fibrillin 1 misprocessing. ADAMTS10 has also been reported to be over expressed in breast cancer tissues and cell lines.
Cellular localization
Secreted; extracellular matrix
Alternative names
- A disintegrin and metalloproteinase with thrombospondin motifs 10 antibody
- A disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 10 antibody
- ADAM metallopeptidase with thrombospondin type 1 motif 10 antibody
see all
Database links
- Entrez Gene: 81794 Human
- Omim: 608990 Human
- SwissProt: Q9H324 Human
- Unigene: 465818 Human
References for Anti-ADAMTS10 antibody - Catalytic domain (ab59813)
ab59813 has not yet been referenced specifically in any publications.
Publishing research using ab59813? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"