Anti-ADAMTS13 antibody (ab28275)

Overview

• Product nameAnti-ADAMTS13 antibodySee all ADAMTS13 primary antibodies ...
• Description
  Rabbit polyclonal to ADAMTS13
• Tested applicationsWB more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  Synthetic peptide based on the propeptide domain of human ADAMTS-13. (Peptide available as ab41248.)

Properties

• FormLiquid
• Storage instructionsStore at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.
• Storage bufferPreservative: 0.05% Sodium Azide
  Constituents: 50% Glycerol
• Concentration information loading...
• PurityImmunogen affinity purified
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Cancer
  • Invasion/microenvironment
  • ECM
  • Extracellular matrix
  • ADAM protein family

  • Signal Transduction
  • Cytoskeleton / ECM
  • Extracellular Matrix
  • ECM Enzymes
  • ADAM Protein Family

  • Cell Biology
  • Proteolysis / Ubiquitin
  • Proteolytic enzymes
  • Metalloprotease
  • ADAM TS

Applications

Target

• FunctionCleaves the vWF multimers in plasma into smaller forms.
• Tissue specificityPlasma. Expressed primarily in liver.
• Involvement in diseaseDefects in ADAMTS13 are the cause of thrombotic thrombocytopenic purpura congenital (TTP) [MIM:274150]; also known as Upshaw-Schulman syndrome (USS). A hematologic disease characterized by hemolytic anemia with fragmentation of erythrocytes, thrombocytopenia, diffuse and non-focal neurologic findings, decreased renal function and fever.
• Sequence similaritiesContains 2 CUB domains.
  Contains 1 disintegrin domain.
  Contains 1 peptidase M12B domain.
  Contains 8 TSP type-1 domains.
• DomainThe pro-domain is not required for folding or secretion and does not perform the common function of maintening enzyme latency.
  The spacer domain is necessary to recognize and cleave vWF. The C-terminal TSP type-1 and CUB domains may modulate this interaction.
• Post-translational
  modificationsMay contain a C-mannosylation site and O-fucosylation sites in the TSP type-1 domains.
  The precursor is processed by a furin endopeptidase which cleaves off the pro-domain.
• Cellular localizationSecreted.

Target information above from: UniProt accession Q76LX8 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 11093 Human
  • Omim: 604134 Human
  • SwissProt: Q76LX8 Human
  • Unigene: 131433 Human

• Alternative names
  A disintegrin and metalloproteinase with thrombospondin motifs 13 antibodyA disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif 13 antibodyA disintegrin like and metalloprotease with thrombospondin type 1 motif 13 antibody

  A disintegrin-like and metalloprotease (Reprolysin type) with thrombospondin type 1 motif 13 antibodyADAM metallopeptidase with thrombospondin type 1 motif 13 antibodyADAM TS antibodyADAM-TS 13 antibodyADAM-TS13 antibodyADAMTS 13 antibodyADAMTS-13 antibodyADAMTS13 antibodyADAMTS13 protein antibodyATS13_HUMAN antibodyC9orf8 antibodyEC 3.4.24.- antibodyTTP antibodyVon Willebrand factor cleaving protease antibodyVon Willebrand factor cleaving protease antibodyvon Willebrand factor-cleaving protease antibodyvWF cleaving protease antibodyvWF CP antibodyvWF-cleaving protease antibodyvWF-CP antibodyvWFCP antibody

  see all

Anti-ADAMTS13 antibody images

• 

  Western blot - ADAMTS13 antibody - Propeptide domain (ab28275)
  All lanes : Anti-ADAMTS13 antibody (ab28275) at 1 µg/ml
  
  Lane 1 : Recombinant Human ATS-13 at 0.08 µg
  Lane 2 : Recombinant Human ATS-13 at 0.04 µg
  Lane 3 : Recombinant Human ATS-13 at 0.02 µg
  
  
  Predicted band size : 154 kDa
  

Protocols

• Recommended WB protocol