Overview

  • Product nameAnti-ADAMTS13 antibody
    See all ADAMTS13 primary antibodies
  • Description
    Goat polyclonal to ADAMTS13
  • Tested applicationsWB, IPmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Gorilla
  • Immunogen

    Synthetic peptide from a region between residue 825 and 875 of human ADAMTS13 (NP_620594.1)

  • Positive control
    • Pooled normal human serum.

Properties

Applications

Our Abpromise guarantee covers the use of ab72335 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
IP
  • Application notesIP: 1-5 µg/µl serum.
    WB: 1/1,000 - 1/10,000. Predicted molecular weight: 154 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionCleaves the vWF multimers in plasma into smaller forms.
    • Tissue specificityPlasma. Expressed primarily in liver.
    • Involvement in diseaseDefects in ADAMTS13 are the cause of thrombotic thrombocytopenic purpura congenital (TTP) [MIM:274150]; also known as Upshaw-Schulman syndrome (USS). A hematologic disease characterized by hemolytic anemia with fragmentation of erythrocytes, thrombocytopenia, diffuse and non-focal neurologic findings, decreased renal function and fever.
    • Sequence similaritiesContains 2 CUB domains.
      Contains 1 disintegrin domain.
      Contains 1 peptidase M12B domain.
      Contains 8 TSP type-1 domains.
    • DomainThe pro-domain is not required for folding or secretion and does not perform the common function of maintening enzyme latency.
      The spacer domain is necessary to recognize and cleave vWF. The C-terminal TSP type-1 and CUB domains may modulate this interaction.
    • Post-translational
      modifications
      May contain a C-mannosylation site and O-fucosylation sites in the TSP type-1 domains.
      The precursor is processed by a furin endopeptidase which cleaves off the pro-domain.
    • Cellular localizationSecreted.
    • Information by UniProt
    • Database links
    • Alternative names
      • A disintegrin and metalloproteinase with thrombospondin motifs 13 antibody
      • A disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif 13 antibody
      • A disintegrin like and metalloprotease with thrombospondin type 1 motif 13 antibody
      • ADAM metallopeptidase with thrombospondin type 1 motif 13 antibody
      • ADAM TS 13 antibody
      • ADAM TS antibody
      • ADAM TS13 antibody
      • ADAM-TS 13 antibody
      • ADAM-TS13 antibody
      • ADAMTS 13 antibody
      • ADAMTS-13 antibody
      • ADAMTS13 antibody
      • ADAMTS13 protein antibody
      • ATS13_HUMAN antibody
      • C9orf8 antibody
      • DKFZp434C2322 antibody
      • EC 3.4.24. antibody
      • FLJ42993 antibody
      • MGC118899 antibody
      • MGC118900 antibody
      • TTP antibody
      • Von Willebrand factor cleaving protease antibody
      • von Willebrand factor-cleaving protease antibody
      • vWF cleaving protease antibody
      • vWF CP antibody
      • vWF-cleaving protease antibody
      • vWF-CP antibody
      • vWFCP antibody
      see all

    Anti-ADAMTS13 antibody images

    • Immunoprecipitation/ Western Blot of ADAMTS13.
      Lane 1: ab72335.
      Lane 2: Control IgG.
      ab72335 at 1µg/ml for WB.
      Pooled normal human serum at 300µl/IP, 10% of IP loaded.
      Chemiluminescence with an exposure time of 30 seconds.
      Note: The antibody was conjugated to agarose to produce agarose immobilized antibody. Used at 35µg of antibody per IP.

    References for Anti-ADAMTS13 antibody (ab72335)

    ab72335 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"