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Products:Signal Transduction >> Cytoskeleton / ECM >> Extracellular Matrix >> ECM Enzymes >> ADAM Protein Family
Overview
Product name
Anti-ADAMTS14 antibody - Catalytic domain
See all ADAMTS14 products (2) ...
Description
Rabbit polyclonal to ADAMTS14 - Catalytic domain
Specificity
We have a range of domain specific antibodies for this target. For a full list please see all ADAMTS14 antibodies.
Tested applications
Cross reactivity
Reacts with
Human
Immunogen
A synthetic peptide based on the catalytic domain of human ADAMTS14
General notes
Immunizing peptide available on request – please contact a member of staff to ask for availability
Properties
Form
Liquid
Storage instructions
Store at -20°C. Stable for 12 months at -20°C
Storage buffer
Preservative: 0.05% Sodium Azide
Constituents: 50% Glycerol, PBS, 500mM Sodium chloride, pH 7.4
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Cell Biology >> Proteolysis / Ubiquitin >> Proteolytic enzymes >> Metalloprotease >> ADAM TS
Signal Transduction >> Cytoskeleton / ECM >> Extracellular Matrix >> ECM Enzymes >> ADAM Protein Family
Applications
Show applications key
Our Abpromise guarantee covers the use of ab59824 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB
Application notes
WB: 1/1000 - 1/5000. Predicted molecular weight: 134 kDa.
The recommended starting concentration for Western blots is 1:1,000 when using colorimetric substrates such as BCIP/NBT, and 1:5,000 for chemiluminescent substrates.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Relevance
ADAMTS14 is a member of the ADAMs family of proteinases with 4 thrombospondin (TS)-like domains. These TS motifs are thought to bind ADAMTS14 to the ECM. ADAMTS14 is closest in homology to ADAMTS3, sharing 63% overall identity. ADAMTS14 has a PLAC (Protease and LACunin) domain at the carboxyterminal end, containing a 6 cysteine conserved repeat. The sequence also contains a prohormone-convertase cleavage site (predicted PC cleavage site is the RKRR252 sequence). Several splice variants of ADAMTS-14 have been reported. ADAMTS14 has been shown to be a potential factor in multiple sclerosis (MS), by linkage analysis. ADAMTS14 is expressed in many tissues including lung, brain, liver and placenta.
Cellular localization
Secreted
Alternative names
- A disintegrin and metalloproteinase with thrombospondin motifs 14 antibody
- ADAM TS14 antibody
- ADAMTS 14 antibody
see all
Database links
- Entrez Gene: 140766 Human
- Omim: 607506 Human
- SwissProt: Q8WXS8 Human
- Unigene: 352156 Human
References for Anti-ADAMTS14 antibody - Catalytic domain (ab59824)
ab59824 has not yet been referenced specifically in any publications.
Publishing research using ab59824? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"