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Products:Signal Transduction >> Cytoskeleton / ECM >> Extracellular Matrix >> ECM Enzymes >> ADAM Protein Family
Overview
Product name
Anti-ADAMTS15 antibody - Propeptide domain
See all ADAMTS15 products (3) ...
Description
Rabbit polyclonal to ADAMTS15 - Propeptide domain
Tested applications
Cross reactivity
Reacts with
Human
Immunogen
Synthetic peptide based on the propeptide region of human ADAMTS-15 ADAMTS15.(Peptide available as ab45243.)
General notes
We have a range of domain specific antibodies for this target. For a full list please see all ADAMTS15 antibodies.
Properties
Form
Liquid
Storage instructions
Store at -20°C. Stable for 12 months at -20°C
Storage buffer
Preservative: 0.05% Sodium Azide
Constituents: 50% Glycerol, PBS, 500mM Sodium chloride, pH 7.4
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Cancer >> Invasion/microenvironment >> ECM >> Extracellular matrix >> ADAM protein family
Signal Transduction >> Cytoskeleton / ECM >> Extracellular Matrix >> ECM Enzymes >> ADAM Protein Family
Applications
Show applications key
Our Abpromise guarantee covers the use of ab45047 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application notes
WB: 1/1000 - 1/5000. Predicted molecular weight: 103 kDa. The recommended starting concentration for Western blots is 1:1,000 when using colorimetric substrates such as BCIP/NBT, and 1:5,000 for chemiluminescent substrates Dilution optimised using Chromogenic detection. Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Target
Relevance
ADAMTS proteases are secreted enzymes containing a prometalloprotease domain of the reprolysin type. The ADAMTS proteases function in processing of procollagens and von Willebrand factor as well as catabolism of aggrecan, versican and brevican. They have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration.
Cellular localization
Secreted
Alternative names
- A disintegrin and metalloproteinase with thrombospondin motifs 15 antibody
- A disintegrin like and metalloprotease reprolysin type with thrombospondin type 1 motif 15 antibody
- A disintegrin like and metalloprotease Reprolysin type with thrombospondin type 1 motif 15 preproprotein antibody
see all
Database links
- Entrez Gene: 170689 Human
- Omim: 607509 Human
- SwissProt: Q32MI6 Human
- SwissProt: Q8TE58 Human
- Unigene: 534221 Human
Protocols
References for Anti-ADAMTS15 antibody - Propeptide domain (ab45047)
This product has been referenced in:
- Molokwu CNet al. Androgen regulates ADAMTS15 gene expression in prostate cancer cells. Cancer Invest 28:698-710 (2010). WB; Human.Read more (PubMed: 20590445) »
See 1 publication for this product
Publishing research using ab45047? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"