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Anti-ADAMTS16 antibody - Catalytic domain (ab59827)

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Overview

Product name

Anti-ADAMTS16 antibody - Catalytic domain
See all ADAMTS16 products (2) ...

Description

Rabbit polyclonal to ADAMTS16 - Catalytic domain

Specificity

We have a range of domain specific antibodies for this target. For a full list please see all ADAMTS16 antibodies.

Tested applications

WBmore details

Cross reactivity

Reacts with

Human

Immunogen

A synthetic peptide based on the catalytic domain of human ADAMTS16

General notes

Immunizing peptide available on request – please contact a member of staff to ask for availability

Properties

Form

Liquid

Storage instructions

Store at -20°C. Stable for 12 months at -20°C

Storage buffer

Preservative: 0.05% Sodium Azide
Constituents: 50% Glycerol, PBS, 500mM Sodium chloride, pH 7.4

Concentration

Concentration information loading...

Purity

Immunogen affinity purified

Clonality

Polyclonal

Isotype

IgG

Research areas

Cell Biology >> Proteolysis / Ubiquitin >> Proteolytic enzymes >> Metalloprotease >> ADAM TS

Applications

Show applications key

Our Abpromise guarantee covers the use of ab59827 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • WB

     

Application notes

WB: 1/1000 - 1/5000. Predicted molecular weight: 136 kDa.
The recommended starting concentration for Western blots is 1:1,000 when using colorimetric substrates such as BCIP/NBT, and 1:5,000 for chemiluminescent substrates.

Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Target

Relevance

ADAMTS16 is a member of the ADAMs family of proteinases with 4 thrombospondin-like domains. ADAMTS16 is closest in homology to ADAMTS18, sharing 57% overall identity. ADAMTS16 is expressed in fetal human lung and kidney, and in adult brain and ovary as well as in osteoarthritic cartilage, prostate and breast tissue. ADAMTS16 contains a prohormone-convertase cleavage site; the predicted PC cleavage site is the RRRR87 sequence in the 1224 and 1072 amino acid forms. This catalytic site is typical of the metalloproteinase catalytic domains, with an HExxHxxxxxH sequence. Several splice variants of ADAMTS16 have been reported.

Cellular localization

Secreted

Alternative names

  • A disintegrin and metalloproteinase with thrombospondin motifs 16 antibody
  • ADAMTS 16 antibody
  • ADAMTS16 antibody
  • EC 3.4.24. antibody

Database links

References for Anti-ADAMTS16 antibody - Catalytic domain (ab59827)

ab59827 has not yet been referenced specifically in any publications.

Publishing research using ab59827? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"