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Products:Cardiovascular >> Angiogenesis >> Adhesion / ECM >> Matrix Metalloproteinases >> MMP
Overview
Product name
Anti-ADAMTS2 antibody
See all ADAMTS2 products (6) ...
Description
Mouse monoclonal to ADAMTS2
Tested applications
Cross reactivity
Reacts with
Rat, Human
Immunogen
Recombinant fragment: KHNDIDVFMP TLPVPTVAME VRPSPSTPLE VPLNASSTNA TEDHPETNAV DEPYKIHGLE DEVQPPNLIP RRPSPYEKTR NQRIQELIDE MRKKEMLGK, corresponding to amino acids 1112-1211 of Human ADAMTS2
KHNDIDVFMP TLPVPTVAME VRPSPSTPLE VPLNASSTNA TEDHPETNAV DEPYKIHGLE DEVQPPNLIP RRPSPYEKTR NQRIQELIDE MRKKEMLGK
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
PBS, pH 7.2
Concentration
Concentration information loading...
Purity
Protein G purified
Clonality
Monoclonal
Isotype
IgG2a
Light chain type
kappa
Research areas
Cell Biology >> Proteolysis / Ubiquitin >> Proteolytic enzymes >> Metalloprotease >> ADAM TS
Cancer >> Invasion/microenvironment >> ECM >> Extracellular matrix >> ADAM protein family
Signal Transduction >> Cytoskeleton / ECM >> Extracellular Matrix >> ECM Enzymes >> MMP
Cardiovascular >> Angiogenesis >> Adhesion / ECM >> Matrix Metalloproteinases >> MMP
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Western blot - ADAMTS2 antibody (ab56735)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab56735 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- 1 Image
WB
Application notes
WB: Use at a concentration of 1-5 µg/ml.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Function
Cleaves the propeptides of type I and II collagen prior to fibril assembly. Does not act on type III collagen. May also play a role in development that is independent of its role in collagen biosynthesis.
Tissue specificity
Expressed at high level in skin, bone, tendon and aorta and at low levels in thymus and brain.
Involvement in disease
Defects in ADAMTS2 are the cause of Ehlers-Danlos syndrome type 7C (EDS7C) [MIM:225410]. EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS7C is marked by extremely fragile tissues, hyperextensible skin and easy bruising. Facial skin contains numerous folds, as in the cutis laxa syndrome.
Sequence similarities
Contains 1 disintegrin domain.
Contains 1 peptidase M12B domain.
Contains 1 PLAC domain.
Contains 4 TSP type-1 domains.
Domain
The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.
Post-translational
modifications
The precursor is cleaved by a furin endopeptidase.
Cellular localization
Secreted > extracellular space > extracellular matrix.
Target information above from: UniProt accessionO95450
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- A disintegrin and metalloproteinase with thrombospondin motifs 2 antibody
- A disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif 2 antibody
- ADAM metallopeptidase with thrombospondin type 1 motif 2 antibody
see all
Database links
- Entrez Gene: 9509 Human
- Entrez Gene: 287899 Rat
- Omim: 604539 Human
- SwissProt: O95450 Human
- Unigene: 23871 Human
- Unigene: 591725 Human
- Unigene: 86986 Rat
Anti-ADAMTS2 antibody images:
Western blot - ADAMTS2 antibody (ab56735)
ADAMTS2 antibody (ab56735) at 1ug/lane + PC-12 cell lysate at 25ug/lane.
References for Anti-ADAMTS2 antibody (ab56735)
ab56735 has not yet been referenced specifically in any publications.
Publishing research using ab56735? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"