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Overview

  • Product nameAnti-ADAMTS4 antibodySee all ADAMTS4 primary antibodies ...
  • Description
    Rabbit polyclonal to ADAMTS4
  • Specificityab111905 is specific for ADAMTS4 and shows no cross-reactivity with other ADAMTS family members.
  • Tested applicationsWB more details
  • Species reactivity
    Reacts with: Cow, Human, Pig
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide: C-VMAHVDPEEP (with a Cysteine residue linker), corresponding to amino acids 390-399 of Mouse ADAMTS4 according to Q8BNJ2.

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI

Properties

Applications

Our Abpromise guarantee covers the use of ab111905 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB WB: Use a concentration of 1 µg/ml. Predicted molecular weight: 90 kDa. This antibody detects ADAMTS4 at ~68, ~53 and 30 kDa protein representing ADAMTS4 and its proteolytic fragments. Depending on the extent of C-terminal processing, several smaller bands may also be seen using this antibody.

Target

  • FunctionCleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-
    -Ala-393' site.
  • Tissue specificityExpressed in brain, lung and heart. Expressed at very low level in placenta and skeletal muscles.
  • Sequence similaritiesContains 1 disintegrin domain.
    Contains 1 peptidase M12B domain.
    Contains 1 TSP type-1 domain.
  • DomainThe spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.
    The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Post-translational
    modifications    The precursor is cleaved by a furin endopeptidase.
  • Cellular localizationSecreted > extracellular space > extracellular matrix.

    • Target information above from: UniProt accession O75173 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
    see all
  • Alternative names
      A disintegrin and metalloproteinase with thrombospondin motifs 4 antibodyA disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif 4 antibodyA disintegrin like and metalloprotease with thrombospondin type 1 motif 4 antibody
      ADAM metallopeptidase with thrombospondin type 1 motif 4 antibodyADAM TS 4 antibodyADAM TS4 antibodyADAM-TS 4 antibodyADAM-TS4 antibodyADAMTS 2 antibodyADAMTS 4 antibodyADAMTS-4 antibodyADAMTS2 antibodyADAMTS4 antibodyADAMTS4 protein antibodyADMP 1 antibodyADMP-1 antibodyADMP1 antibodyAggrecanase 1 antibodyAggrecanase-1 antibodyAggrecanase1 antibodyATS4_HUMAN antibodyKIAA0688 antibody
    see all

References for Anti-ADAMTS4 antibody (ab111905)

ab111905 has not yet been referenced specifically in any publications.

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