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ADAMTS4 peptide (Carboxyterminal end) (ab41235)

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Overview

  • Product nameADAMTS4 peptide (Carboxyterminal end)See all ADAMTS4 proteins and peptides ...
  • Protein descriptionThis peptide was used as an immunogen for ab28285 - ADAMTS4 antibody - Carboxyterminal end.

    • Properties

  • Purity> 95 % by SDS-PAGE
  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: 0.001% Tween 20, 30mM HEPES, 2mM EDTA, 150mM Sodium chloride, pH 6.75
  • Concentration information loading...
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab41235 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    WB
    ELISA
  • Application notesELISA: Use at an assay dependent dilution. WB: Use at an assay dependent dilution. This peptide can be used with studies using ab28285. Dilution optimised using Chromogenic detection. Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

    • Protein info

    • Alternative names
        A disintegrin and metalloproteinase with thrombospondin motifs 4A disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif 4A disintegrin like and metalloprotease with thrombospondin type 1 motif 4
        ADAM metallopeptidase with thrombospondin type 1 motif 4ADAM TS 4ADAM TS4ADAM-TS 4ADAM-TS4ADAMTS 2ADAMTS 4ADAMTS-4ADAMTS2ADAMTS4ADAMTS4 proteinADMP 1ADMP-1ADMP1Aggrecanase 1Aggrecanase-1Aggrecanase1ATS4_HUMANKIAA0688
      see all
  • FunctionCleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-
    -Ala-393' site.
  • Tissue specificityExpressed in brain, lung and heart. Expressed at very low level in placenta and skeletal muscles.
  • Sequence similaritiesContains 1 disintegrin domain.
    Contains 1 peptidase M12B domain.
    Contains 1 TSP type-1 domain.
  • DomainThe spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.
    The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Post-translational
    modifications    The precursor is cleaved by a furin endopeptidase.
  • Cellular localizationSecreted > extracellular space > extracellular matrix.

    • Target information above from: UniProt accession O75173 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for ADAMTS4 peptide (Carboxyterminal end) (ab41235)

    ab41235 has not yet been referenced specifically in any publications.

    Publishing research using ab41235 ? Please let us know so that we can cite the reference in this datasheet

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