|
|
|
|
|
Product Name
|
ADAMTS8 peptide (Carboxyterminal end)
|
|
Product type
|
Proteins and Peptides
|
|
Peptide
|
This peptide was used as an immunogen for ab28558 - ADAMTS8 antibody - Carboxyterminal end.
|
|
Specificity
|
We have a range of domain specific antibodies for this target. For a full list please see all ADAMTS8 antibodies
|
|
Tested applications
(see key)
|
ELISA, WB
|
|
Application notes
(see key)
|
Recommended dilutions
ELISA: Use at an assay dependent dilution. WB: Use at an assay dependent dilution. This peptide can be used with studies using ab28558. Dilution optimised using Chromogenic detection. Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
|
|
Research areas
|
Cell Biology >> Proteolysis / Ubiquitin >> Proteolytic enzymes >> Metalloprotease >> ADAM TS
Cancer >> Invasion/microenvironment >> ECM >> Extracellular matrix >> ADAM protein family
Signal Transduction >> Cytoskeleton / ECM >> Extracellular Matrix >> ECM Enzymes >> ADAM Protein Family
|
|
Relevance
|
ADAMTS proteases are secreted enzymes containing a prometalloprotease domain of the reprolysin type. The ADAMTS proteases function in processing of procollagens and von Willebrand factor as well as catabolism of aggrecan, versican and brevican. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration.
A member of the metalloproteinase family containing disintegrin like domains (ADAMs), the function of ADAMTS8 is still poorly understood. ADAMTS8 contains the canonical HExxHxxxxxH zinc metalloproteinase motif, and has been shown to be proteolytically active on a range of substrates. ADAMTS8 is inhibited by the endogenous MMP inhibitors, TIMP1, 2, 3 and 4, but most efficiently by TIMP3. In addition to the metalloprotease domain, ADAMTS8 has a propeptide domain, a Prohormone Convertase (PC, furin) cleavage site, a cysteine rich domain and thrombospondin 1 like domains.
|
|
|
ADAMTS8 peptide (Carboxyterminal end) (ab41242) |
|
Purity
|
>95% by SDS-PAGE
|
|
Storage buffer
|
Preservative: None
Constituents: 0.001% Tween 20, 30mM HEPES, 2mM EDTA, 150mM Sodium chloride, pH 6.75
|
|
Form
|
Liquid
|
|
Concentration
|
1.000 mg/ml
|
|
Storage instructions
|
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
|
| |
At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this ADAMTS8 peptide (Carboxyterminal end) is on this datasheet. But please do contact us if you would like any reassurance! |
 |
|
| |
|
Search PubMed (MEDLINE) for references to ADAMTS8
|
| |
ADAMTS8 peptide (Carboxyterminal end) - more information
|
Customer reviews (feedback) regarding ADAMTS8 peptide (Carboxyterminal end) |
Customer FAQs regarding ADAMTS8 peptide (Carboxyterminal end) |
Protocols for ADAMTS8 peptide (Carboxyterminal end) |
Price and availability of products related to ADAMTS8 peptide (Carboxyterminal end) |
| |
ADAMTS8 peptide (Carboxyterminal end) - related products:
|
|
|
| |
ADAMTS8 peptide (Carboxyterminal end) - other tools:
|
Contact Abcam with a Technical Enquiry about ADAMTS8 peptide (Carboxyterminal end) |
| |
All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
Pricing information loading
