Anti-AC6 antibody (ab14781)
Key features and details
- Rabbit polyclonal to AC6
- Suitable for: WB
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
Overview
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Product name
Anti-AC6 antibody -
Description
Rabbit polyclonal to AC6 -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Mouse, Rat, Human -
Immunogen
Synthetic peptide corresponding to Rat AC6 aa 1-100 (N terminal) conjugated to keyhole limpet haemocyanin.
Database link: Q03343 -
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
Preservative: 0.02% Sodium azide -
Concentration information loading...
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Purity
Immunogen affinity purified -
Purification notes
The affinity-purified antibodies are purified on antigen-sepharose affinity column and supplied in antibody stabilization buffer containing preservatives with low viscosity and cryogenic properties. -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab14781 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB | (1) |
1/500. Predicted molecular weight: 130 kDa.
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Notes |
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WB
1/500. Predicted molecular weight: 130 kDa. |
Target
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Function
Membrane-bound, calcium-inhibitable adenylyl cyclase. -
Sequence similarities
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Contains 2 guanylate cyclase domains. -
Cellular localization
Membrane. - Information by UniProt
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Database links
- Entrez Gene: 112 Human
- Entrez Gene: 11512 Mouse
- Entrez Gene: 25289 Rat
- Omim: 600294 Human
- SwissProt: O43306 Human
- SwissProt: Q01341 Mouse
- SwissProt: Q03343 Rat
- Unigene: 525401 Human
see all -
Alternative names
- AC6 antibody
- ACVI antibody
- ADCY 6 antibody
see all
Datasheets and documents
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Datasheet download
References (6)
ab14781 has been referenced in 6 publications.
- Wu H et al. MiR-27a-3p binds to TET1 mediated DNA demethylation of ADCY6 regulates breast cancer progression via epithelial-mesenchymal transition. Front Oncol 12:957511 (2022). PubMed: 35978806
- Zhang X et al. Endogenous glutamate determines ferroptosis sensitivity via ADCY10-dependent YAP suppression in lung adenocarcinoma. Theranostics 11:5650-5674 (2021). PubMed: 33897873
- Hampson E et al. P-Rex1 Controls Sphingosine 1-Phosphate Receptor Signalling, Morphology, and Cell-Cycle Progression in Neuronal Cells. Cells 10:N/A (2021). PubMed: 34572121
- Johnson GP et al. Mesenchymal stem cell mechanotransduction is cAMP dependent and regulated by adenylyl cyclase 6 and the primary cilium. J Cell Sci 131:N/A (2018). PubMed: 30301777
- Ikoma-Seki K et al. Role of LRP1 and ERK and cAMP Signaling Pathways in Lactoferrin-Induced Lipolysis in Mature Rat Adipocytes. PLoS One 10:e0141378 (2015). WB ; Rat . PubMed: 26506094
- Grünberger C et al. The calcium paradoxon of renin release: calcium suppresses renin exocytosis by inhibition of calcium-dependent adenylate cyclases AC5 and AC6. Circ Res 99:1197-206 (2006). WB ; Mouse . PubMed: 17068292