Overview

  • Product nameAnti-ADCY9 antibodySee all ADCY9 primary antibodies ...
  • Description
    Rabbit polyclonal to ADCY9
  • SpecificityThe antibody does not cross reacts with other adenylate cyclases (AC1 to 8).
  • Tested applicationsWB more details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide unique to PAC9 protein was used to generate antibodies in rabbit. (unfortunately, the amino acid sequence is considered to be commercially sensitive). All peptides were amidated before conjugation.

Properties

Applications

Our Abpromise guarantee covers the use of ab14783 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB 1/500. Detects a band of approximately 110 kDa (predicted molecular weight: 150 kDa).

Target

  • RelevanceThe membrane-bound adenylyl cyclases (ACs) represent one of the major families of effector enzymes for G protein-coupled receptors (GPCRs). Using the high inter-species homology of mammalian AC isoforms, nine Adenylyl cyclase (AC) isoforms, encoded by separate genes, have been identified until today. Human adenylate cyclase genes comprise of 11 to 26 exons, which are distributed over 16 to 430kb. The expression profile of these 9 AC isoforms in a panel of 16 human tissues and in human embryonic kidney (HEK) cells have been demonstrated earlier. The cAMP synthesizing enzymes are found in two forms: cytosolic (soluble) and membrane-bound (particulate). Stimulation of adenylate cyclases produce cAMP form ATP in response to the activation of GPCRs by various hormones, neurotransmitters and other regulatory molecules. cAMP, in subsequent steps down the signal transduction pathway, can stimulate cAMP-dependent protein kinase A (cPKA), and several other target molecules. Activation of cPKA can phosphorylate a broad range of substrates that regulate various metabolic pathways, gene expression, and affect memory functions etc. The stimulation of adenylate cyclases starts with interactions with GPCRs mediated signals initiated by Gs and Gi heterotrimeric G-proteins. The interaction of GPCR agonist (eg. Interaction of isopreternol to beta2 receptors) catalyses the exchange of GDP to GTP that is bound to G proteins. The GTP binding reduces the affinity of GsƒÑ to other GTP binding proteins and Gs-GTP complex stimulate the adenylate cyclase. In last several years, new members of particulate and soluble adenylate cyclase family have been identified and significant progress is made in understanding of the molecular mechanisms that underlie the regulation of these families of enzymes.
  • Cellular localizationIntegral membrane protein.
  • Database links
  • Alternative names
    • ADCY 9 antibody
    • Adenylate cyclase 9 antibody
    • Adenylate cyclase type 9 antibody
    • Adenylate cyclase type IX antibody
    • Adenylyl cyclase 9 antibody
    • ATP pyrophosphate lyase 9 antibody
    • KIAA0520 antibody
    • Type IX adenylyl cyclase antibody
    • Type IX ATP pyrophosphate lyase antibody
    see all

References for Anti-ADCY9 antibody (ab14783)

ab14783 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"