Anti-ADCY9 antibody (ab14783)

Overview

• Product nameAnti-ADCY9 antibodySee all ADCY9 primary antibodies ...
• Description
  Rabbit polyclonal to ADCY9
• SpecificityThe antibody does not cross reacts with other adenylate cyclases (AC1 to 8).
• Tested applicationsWB more details
• Species reactivity
  Reacts with: Mouse, Rat, Human
  
• Immunogen

  Synthetic peptide unique to PAC9 protein was used to generate antibodies in rabbit. (unfortunately, the amino acid sequence is considered to be commercially sensitive). All peptides were amidated before conjugation.

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Storage bufferPreservative: 0.02% Sodium Azide
  
• Concentration information loading...
• PurityImmunogen affinity purified
• Purification notesThe antibodies are affinity purified against immobilized antigen based affinity chromatography which yielded epitope-specific antibodies.
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Metabolism
  • Pathways and Processes
  • Metabolic signaling pathways
  • Energy transfer pathways
  • Integration of energy

  • Metabolism
  • Types of disease
  • Cancer

  • Cancer
  • Cancer Metabolism
  • Metabolic signaling pathway
  • Integration of energy metabolism

  • Signal Transduction
  • Signaling Pathway
  • G Protein Signaling
  • GPCR

Applications

Target

• RelevanceThe membrane-bound adenylyl cyclases (ACs) represent one of the major families of effector enzymes for G protein-coupled receptors (GPCRs). Using the high inter-species homology of mammalian AC isoforms, nine Adenylyl cyclase (AC) isoforms, encoded by separate genes, have been identified until today. Human adenylate cyclase genes comprise of 11 to 26 exons, which are distributed over 16 to 430kb. The expression profile of these 9 AC isoforms in a panel of 16 human tissues and in human embryonic kidney (HEK) cells have been demonstrated earlier. The cAMP synthesizing enzymes are found in two forms: cytosolic (soluble) and membrane-bound (particulate). Stimulation of adenylate cyclases produce cAMP form ATP in response to the activation of GPCRs by various hormones, neurotransmitters and other regulatory molecules. cAMP, in subsequent steps down the signal transduction pathway, can stimulate cAMP-dependent protein kinase A (cPKA), and several other target molecules. Activation of cPKA can phosphorylate a broad range of substrates that regulate various metabolic pathways, gene expression, and affect memory functions etc. The stimulation of adenylate cyclases starts with interactions with GPCRs mediated signals initiated by Gs and Gi heterotrimeric G-proteins. The interaction of GPCR agonist (eg. Interaction of isopreternol to beta2 receptors) catalyses the exchange of GDP to GTP that is bound to G proteins. The GTP binding reduces the affinity of GsƒÑ to other GTP binding proteins and Gs-GTP complex stimulate the adenylate cyclase. In last several years, new members of particulate and soluble adenylate cyclase family have been identified and significant progress is made in understanding of the molecular mechanisms that underlie the regulation of these families of enzymes.
• Cellular localizationIntegral membrane protein.
• Database links
  • Entrez Gene: 115 Human
  • Entrez Gene: 11515 Mouse
  • Omim: 603302 Human
  • SwissProt: O60503 Human
  • SwissProt: P51830 Mouse
  • Unigene: 20196 Human
  • Unigene: 4294 Mouse

• Alternative names
  ADCY 9 antibodyAdenylate cyclase 9 antibodyAdenylate cyclase type 9 antibody

  Adenylate cyclase type IX antibodyAdenylyl cyclase 9 antibodyATP pyrophosphate lyase 9 antibodyKIAA0520 antibodyType IX adenylyl cyclase antibodyType IX ATP pyrophosphate lyase antibody

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