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Products:Signal Transduction >> Metabolism >> Amino Acids
Overview
Product name
ADI1 protein
Protein description
Recombinant full length protein, corresponding to amino acids 1-179 of Human ADI1. T7 tag at N terminus.
Expression host
E. coli
Properties
Purity
>95% by SDS-PAGE
Form
Liquid
Storage instructions
Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.002% Sodium Azide
Constituents: 10mM Tris, 0.1% Triton X-100, pH 8.0
Concentration
Concentration information loading...
Additional notes
Stability: 6-12 months at -70ºC.
Sequence notes
MVQAWYMDDA PGDPRQPHRP DPGRPVGLEQ LRRLGVLYWK LDADKYENDP ELEKIRRERN YSWMDIITIC KDKLPNYEEK IKMFYEEHLH LDDEIRYILD GSGYFDVRDK EDQWIRIFME KGDMVTLPAG IYHRFTVDEK NYTKAMRLFV GEPVWTAYNR PADHFEARGQ YVKFLAQTA
Research areas
Cancer >> Tumor biomarkers >> Other
Signal Transduction >> Metabolism >> Amino Acids
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SDS-PAGE - ADI1 protein (ab40086)
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Applications
Show applications key
Our Abpromise guarantee covers the use of ab40086 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
MS: Use at an assay dependent dilution.
SDS-PAGE: Use at an assay dependent dilution.
Protein info
Function
Has aci-reductone dioxygenase (ARD) activity and can function in the 5-methylthioadenosine (MTA) methionine salvage pathway. Down-regulates cell migration mediated by MMP14. Necessary for hepatitis C virus replication in an otherwise non-permissive cell line.
Tissue specificity
Detected in heart, colon, lung, stomach, brain, spleen, liver, skeletal muscle and kidney.
Pathway
Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6.
Sequence similarities
Belongs to the acireductone dioxygenase (ARD) family.
Cellular localization
Cell membrane. Nucleus.
Target information above from: UniProt accessionQ9BV57
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
ADI1 protein images:
References for ADI1 protein (ab40086)
ab40086 has not yet been referenced specifically in any publications.
Publishing research using ab40086? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"