AF-DX 116 (Otenzepad), M2 antagonist (ab120152)
Key features and details
- M2 antagonist
- CAS Number: 102394-31-0
- Soluble in DMSO to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
-
Product name
AF-DX 116 (Otenzepad), M2 antagonist -
Description
M2 antagonist -
Alternative names
- Otenzepad
-
Biological description
Selective M2 receptor antagonist.
-
CAS Number
102394-31-0 -
Chemical structure
Properties
-
Chemical name
11-[[2-[(Diethylamino)methyl]-1-piperidinyl]acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one -
Molecular weight
421.54 -
Molecular formula
C24H31N5O2 -
PubChem identifier
107867 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES
O=C(CN1CCCCC1CN(CC)CC)N4c2ccccc2C(=O)Nc3cccnc34 -
Source
Synthetic
-
Research areas
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (3)
ab120152 has been referenced in 3 publications.
- Tryon SC et al. Differential Regulation of Prelimbic and Thalamic Transmission to the Basolateral Amygdala by Acetylcholine Receptors. J Neurosci 43:722-735 (2023). PubMed: 36535767
- Choisy SC et al. Acute desensitization of acetylcholine and endothelin-1 activated inward rectifier K(+) current in myocytes from the cardiac atrioventricular node. Biochem Biophys Res Commun 423:496-502 (2012). PubMed: 22683635
- Gorini C et al. Endogenous inhibition of the trigeminally evoked neurotransmission to cardiac vagal neurons by muscarinic acetylcholine receptors. J Neurophysiol 104:1841-8 (2010). PubMed: 20719927