Overview

  • Product name
    AG-126
  • Description
    Tyrosine kinase inhibitor
  • Biological description
    Tyrosine kinase inhibitor. Inhibits glucocorticoid induced COX-2 activity (IC50 = 15 μM). Blocks lipopolysaccharide (LPS) induced TNFα synthesis and tyrosine phosphorylation of ERK2. Cell-permeable. Shows anti-inflammtory activity. Active in vivo.
  • Purity
    > 98%

Properties

References

This product has been referenced in:
  • Cuzzocrea S  et al. The tyrosine kinase inhibitor tyrphostin AG126 reduces the development of acute and chronic inflammation. Am J Pathol 157:145-58 (2000). Read more (PubMed: 10880385) »
  • Zakar T  et al. Tyrosine kinase inhibitors block the glucocorticoid stimulation of prostaglandin endoperoxide H synthase expression in amnion cells. Can J Physiol Pharmacol 77:138-42 (1999). Read more (PubMed: 10535705) »
  • Ruetten H & Thiemermann C Effects of tyrphostins and genistein on the circulatory failure and organ dysfunction caused by endotoxin in the rat: a possible role for protein tyrosine kinase. Br J Pharmacol 122:59-70 (1997). Read more (PubMed: 9298529) »
  • Novogrodsky A  et al. Prevention of lipopolysaccharide-induced lethal toxicity by tyrosine kinase inhibitors. Science 264:1319-22 (1994). Read more (PubMed: 8191285) »

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