Overview

  • Product name
    AG 1296
  • Description
    Potent specific PDGF receptor tyrosine kinase inhibitor
  • Biological description
    Potent specific platelet-derived growth factor (PDGF) receptor tyrosine kinase inhibitor (IC50 values are 1.0 μM and 0.8 μM at PDGF α and β-receptors respectively). Cell-permeable.
  • Purity
    > 99%

Properties

    References for AG 1296 (ab141170)

    This product has been referenced in:
    • Strutz F  et al. TGF-beta 1 induces proliferation in human renal fibroblasts via induction of basic fibroblast growth factor (FGF-2). Kidney Int 59:579-92 (2001). Read more (PubMed: 11168939) »
    • Kovalenko M  et al. Phosphorylation site-specific inhibition of platelet-derived growth factor beta-receptor autophosphorylation by the receptor blocking tyrphostin AG1296. Biochemistry 36:6260-9 (1997). Read more (PubMed: 9174341) »
    • Kovalenko M  et al. Selective platelet-derived growth factor receptor kinase blockers reverse sis-transformation. Cancer Res 54:6106-14 (1994). Read more (PubMed: 7954456) »

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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