Potent specific PDGF receptor tyrosine kinase inhibitor
Potent specific platelet-derived growth factor (PDGF) receptor tyrosine kinase inhibitor (IC50 values are 1.0 μM and 0.8 μM at PDGF α and β-receptors respectively). Cell-permeable.
Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions.
Soluble in DMSO to 100 mM and in ethanol to 10 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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Kovalenko M et al. Phosphorylation site-specific inhibition of platelet-derived growth factor beta-receptor autophosphorylation by the receptor blocking tyrphostin AG1296. Biochemistry36:6260-9 (1997).
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Kovalenko M et al. Selective platelet-derived growth factor receptor kinase blockers reverse sis-transformation. Cancer Res54:6106-14 (1994).
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