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Products:Signal Transduction >> Signaling Pathway >> Calcium Signaling >> Other
This fast track antibody is not yet fully characterised. It is subject to these terms and conditions
Overview
Product name
Anti-AGRP antibody
See all AGRP products (4) ...
Description
Goat polyclonal to AGRP
This product is a fast track antibody. It has been affinity purified and shows high titre values against the immunizing peptide by ELISA. Read the terms of use »
Specificity
This antibody is expected to recognise both reported isoforms (as represented by NP_001129; NP_015531).
Cross reactivity
Predicted to work with
Mouse, Dog, Human, Chimpanzee
Immunogen
Synthetic peptide: (C)RKLGTAMNPCSRT, corresponding to C terminal amino acids 120-132 of Human AGRP
(C)RKLGTAM NPCSRT
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
Preservative: 0.02% Sodium Azide
Constituents: 0.5% BSA, Tris buffered saline. pH 7.3
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Purification notes
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Clonality
Polyclonal
Isotype
IgG
Research areas
Cardiovascular >> Lipids / Lipoproteins >> Fatty Acids >> Metabolism
Neuroscience >> Endocrine system >> Hypothalamic pituitary adrenal axis
Neuroscience >> Neurology process >> Metabolism
Signal Transduction >> Signaling Pathway >> Calcium Signaling >> Other
Applications
Application notes
This antibody gave a positive result in ELISA against the immunizing peptide. Antibody detection limit dilution 1:32,000.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Function
Plays a role in weight homeostasis. Plays a role in the central control of feeding. Reduces food intake. Inhibits cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Acts primarily on MC3R and MC4R. Has very low activity with MC5R.
Tissue specificity
Expressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with a lower level of expression occurring in testis, lung, and kidney.
Involvement in disease
Genetic variations in AGRP may be a cause of obesity (OBESITY) [MIM:601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.
Sequence similarities
Contains 1 agouti domain.
Domain
The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.
Cellular localization
Secreted. Golgi apparatus lumen.
Target information above from: UniProt accessionO00253
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- Agouti Related Protein Homolog antibody
- Agouti-related protein antibody
- Agrp antibody
see all
Database links
- Entrez Gene: 181 Human
- Entrez Gene: 11604 Mouse
- Omim: 602311 Human
- SwissProt: O00253 Human
- SwissProt: P56473 Mouse
- Unigene: 104633 Human
- Unigene: 441696 Mouse
References for Anti-AGRP antibody (ab32882)
ab32882 has not yet been referenced specifically in any publications.
Publishing research using ab32882? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"