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Products:Epigenetics and Nuclear Signaling >> Transcription >> Cancer susceptibility >> Tumor Suppressors
Overview
Product name
Anti-AIM2 antibody
See all AIM2 products (4) ...
Description
Rabbit polyclonal to AIM2
Tested applications
WB, ELISAmore details
Cross reactivity
Reacts with
Human
Predicted to work with
Zebrafish
Immunogen
Synthetic peptide (Human)
Positive control
Fetal lung lysate
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: 2% Sucrose, PBS
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Cancer >> Oncoproteins/suppressors >> Tumor suppressors >> Other
Epigenetics and Nuclear Signaling >> Transcription >> Cancer susceptibility >> Tumor Suppressors
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Western blot - AIM2 antibody (ab76423)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab76423 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- 1 Image
WB
ELISA
Application notes
ELISA: Use at an assay dependent dilution. Titre using peptide based assay: 1/62500.
WB: Use at a concentration of 1 µg/ml. Predicted molecular weight: 39 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Function
Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.
Tissue specificity
Expressed in spleen, small intestine, peripheral blood leukocytes, and testis.
Sequence similarities
Belongs to the HIN-200 family.
Contains 1 DAPIN domain.
Contains 1 HIN-200 domain.
Cellular localization
Nucleus.
Target information above from: UniProt accessionO14862
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- Absent in melanoma 2 antibody
- AIM 2 antibody
- Aim2 antibody
see all
Database links
- Entrez Gene: 9447 Human
- Omim: 604578 Human
- SwissProt: O14862 Human
- Unigene: 281898 Human
Anti-AIM2 antibody images:
Western blot - AIM2 antibody (ab76423)
Anti-AIM2 antibody (ab76423) at 1 µg/ml (in 5% skim milk / PBS buffer) + Fetal lung lysate at 10 µg
Secondary
HRP conjugated anti-Rabbit IgG at 1/50000 dilution
Predicted band size : 39 kDa
Observed band size : 40 kDa (why is the actual band size different from the predicted?)
Additional bands at : >90 kDa. We are unsure as to the identity of these extra bands.
References for Anti-AIM2 antibody (ab76423)
This product has been referenced in:
- Zhang Xet al. Cutting Edge: Ku70 Is a Novel Cytosolic DNA Sensor That Induces Type III Rather Than Type I IFN. J Immunol 186:4541-5 (2011). WB; Human.Read more (PubMed: 21398614) »
See 1 publication for this product
Publishing research using ab76423? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"