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Products:Neuroscience >> Neurology process >> Neurodegenerative disease >> Parkinson's disease >> Parkin / PARK
Overview
Product name
Anti-AIMP2/p38 antibody
See all AIMP2/p38 products (5) ...
Description
Mouse polyclonal to AIMP2/p38
Specificity
This antibody is reactive against mammalian transfected lysate.
Tested applications
Cross reactivity
Reacts with
Human
Immunogen
Full length AIMP2/p38 protein (Human)
Positive control
AIMP2/p38 transfected 293T cell lysate
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: 1X PBS, pH 7.2
Concentration
Concentration information loading...
Purity
Protein G purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Cell Biology >> Proteolysis / Ubiquitin >> Proteasome / Ubiquitin >> Proteasome
Neuroscience >> Neurology process >> Neurodegenerative disease >> Parkinson's disease >> Parkin / PARK
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Western blot - AIMP2/p38 antibody (ab67471)
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Applications
Show applications key
Our Abpromise guarantee covers the use of ab67471 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- 1 Image
WB
Application notes
WB: 1/500 - 1/1000. Detects a band of approximately 35 kDa (predicted molecular weight: 35 kDa).
Detection Antibody Pair.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Function
Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor.
Sequence similarities
Contains 1 GST C-terminal domain.
Post-translational
modifications
Phosphorylated on serine residues in response to UV irradiation.
Ubiquitinated by PARK2, leading to its degradation by the proteasome. Mutant PARK2 fails to ubiquitinate AIMP2 efficiently, allowing its accumulation which may contribute to neurodegeneration associated with Parkinson disease.
Cellular localization
Cytoplasm > cytosol. Nucleus. Following DNA damage, dissociates from the aminoacyl-tRNA synthase complex and translocates from the cytoplasm to the nucleus.
Target information above from: UniProt accessionQ13155
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- JTV 1 protein antibody
- JTV 1 protein antibody
- AIMP2 antibody
see all
Database links
- Entrez Gene: 7965 Human
- Omim: 600859 Human
- SwissProt: Q13155 Human
- Unigene: 301613 Human
- Unigene: 728827 Human
Anti-AIMP2/p38 antibody images:
Western blot - AIMP2/p38 antibody (ab67471)
All lanes : Anti-AIMP2/p38 antibody (ab67471) at 1/500 dilution
Lane 1 : AIMP2/p38 transfected 293T cell lysate
Lane 2 : Non-transfected 293T cell lysate
Lysates/proteins at 25 µg per lane.
Secondary
Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution
Predicted band size : 35 kDa
Observed band size : 35 kDa
References for Anti-AIMP2/p38 antibody (ab67471)
ab67471 has not yet been referenced specifically in any publications.
Publishing research using ab67471? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"