Anti-AIPL1 antibody (ab108538)

Overview

• Product nameAnti-AIPL1 antibodySee all AIPL1 primary antibodies ...
• Description
  Rabbit polyclonal to AIPL1
• Tested applicationsWB, ELISA, IHC-P more details
• Species reactivity
  Reacts with: Mouse, Human
  Predicted to work with: Rat
• Immunogen

  Recombinant fragment, corresponding to amino acids 57-320 of Human AIPL1 (BC012055).

• Positive controlMouse brain and Human fetal heart lysates; Human fetal heart tissue

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
• Storage bufferPreservative: 0.02% Sodium Azide
  Constituents: PBS, pH 7.2
• Concentration information loading...
• PurityProtein A purified
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Signal Transduction
  • Protein Trafficking
  • Chaperones
  • Other Chaperones

  • Neuroscience
  • Sensory System
  • Visual system

Applications

Target

• FunctionMay be important in protein trafficking and/or protein folding and stabilization.
• Tissue specificityHighly expressed in retina. Specifically localized to the developing photoreceptor layer and within the photoreceptors of the adult retina.
• Involvement in diseaseDefects in AIPL1 are the cause of Leber congenital amaurosis type 4 (LCA4) [MIM:604393]. LCA designates a clinically and genetically heterogeneous group of childhood retinal degenerations, generally inherited in an autosomal recessive manner. Affected infants have little or no retinal photoreceptor function as tested by electroretinography. LCA represents the most common genetic cause of congenital visual impairment in infants and children.
• Sequence similaritiesContains 1 PPIase FKBP-type domain.
  Contains 3 TPR repeats.
• Cellular localizationCytoplasm. Nucleus.

Target information above from: UniProt accession Q9NZN9 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 23746 Human
  • Entrez Gene: 114230 Mouse
  • Entrez Gene: 59110 Rat
  • Omim: 604392 Human
  • SwissProt: Q9NZN9 Human
  • SwissProt: Q924K1 Mouse
  • SwissProt: Q9JLG9 Rat
  • Unigene: 279887 Human

  • Unigene: 95707 Mouse
  • Unigene: 102037 Rat

  see all

• Alternative names
  A930007I01Rik antibodyAipl1 antibodyAIPL1_HUMAN antibody

  AIPL2 antibodyAryl hydrocarbon interacting protein like 1 antibodyAryl hydrocarbon receptor interacting protein like 1 antibodyAryl-hydrocarbon-interacting protein-like 1 antibodyLCA4 antibodyMGC25485 antibodyOTTHUMP00000128207 antibodyOTTMUSP00000006382 antibodyRP23-401C17.1 antibody

  see all

Anti-AIPL1 antibody images

• 

  Western blot - AIPL1 antibody (ab108538)
  All lanes : Anti-AIPL1 antibody (ab108538) at 1/1000 dilution
  
  Lane 1 : Mouse brain lysate
  Lane 2 : Human fetal heart lysate
  
  
  Predicted band size : 44 kDa
  
• 

  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - AIPL1 antibody (ab108538)
  ab108538, at 1/100 dilution, staining AIPL1 in formalin-fixed, paraffin-embedded Human fetal heart by Immunohistochemistry.