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IHC-P - AKR1B10 antibody (ab57547)
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Western blot - AKR1B10 antibody (ab57547)
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Product Name
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AKR1B10 antibody
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See all AKR1B10 antibodies (4)...
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Product type
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Primary antibodies
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Description
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Mouse monoclonal to AKR1B10
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Immunogen
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Recombinant fragment: VSKLWPTFFE RPLVRKAFEK TLKDLKLSYL DVYLIHWPQG FKSGDDLFPK DDKGNAIGGK ATFLDAWE, corresponding to amino acids 76-144 of Human AKR1B10
BLAST 'VSKLWPTFFE RPLVRKAFEK TLKDLKLSYL DVYLIHWPQG FKSGDDLFPK DDKGNAIGGK ' with  or 
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Reacts with
(species key)
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Hu
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Tested applications
(see key)
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IHC-P, WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
WB: Use at a concentration of 1-5 µg/ml.
IHC-P: Use at a concentration of 3 µg/ml.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Cytoplasmic
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Research areas
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Cancer >> Tumor biomarkers >> Enzymes >> Other
Signal Transduction >> Metabolism >> Drug metabolism
Signal Transduction >> Metabolism >> Energy Metabolism
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Relevance
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ARK1B10 is a NADPH dependant enzyme with an ability to efficiently reduce aliphatic and aromatic aldehydes. A 316 A.A protein, AKR1B10 is a highly efficient retinal reductase constituting the first cytosolic NADP (H) dependent retinal reductase described in humans and is characterized by the presence of a novel NADP binding motif. Due to its ability to convert glucose to sorbitol, AKR1B10 may have a role in development of secondary diabetic complications. It is abundantly expressed in adrenal gland, small intestine and colon, with lower levels in liver, thymus, prostate, testis, and skeletal muscle and its levels are up regulated in certain cancers such as hepatocellular carcinoma.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Mouse
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Clonality
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Monoclonal
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Isotype
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IgG2a
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Light chain type
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kappa
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Purity
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Protein G purified
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Storage buffer
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Preservative: None
PBS, pH 7.2
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Form
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Liquid
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Concentration
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1.000 mg/ml
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this AKR1B10 antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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AKR1B10 antibody images:
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 IHC-P - AKR1B10 antibody (ab57547)
AKR1B10 antibody (ab57547) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human colon.
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Western blot - AKR1B10 antibody (ab57547)
Predicted band size : 36 kDa
AKR1B10 antibody (ab57547) at 1ug/lane + HepG2 cell lysate at 25ug/lane.
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Search PubMed (MEDLINE) for references to AKR1B10
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AKR1B10 antibody - more information
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AKR1B10 antibody - other tools:
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