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SDS-PAGE - AKR1B10 protein (Human) (ab85415)
(enlarge)
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Product Name
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AKR1B10 protein (Human)
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Product type
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Proteins and Peptides
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Peptide
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Recombinant full length Human AKR1B10; amino acids 1-316, 36kDa. Swiss ID = O60218.
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Tested applications
(see key)
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SDS-PAGE
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Application notes
(see key)
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Recommended dilutions
SDS-PAGE: Use at an assay dependent dilution.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Research areas
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Cancer >> Tumor biomarkers >> Enzymes >> Other
Signal Transduction >> Metabolism >> Drug metabolism
Signal Transduction >> Metabolism >> Energy Metabolism
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Relevance
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ARK1B10 is a NADPH dependant enzyme with an ability to efficiently reduce aliphatic and aromatic aldehydes. A 316 A.A protein, AKR1B10 is a highly efficient retinal reductase constituting the first cytosolic NADP (H) dependent retinal reductase described in humans and is characterized by the presence of a novel NADP binding motif. Due to its ability to convert glucose to sorbitol, AKR1B10 may have a role in development of secondary diabetic complications. It is abundantly expressed in adrenal gland, small intestine and colon, with lower levels in liver, thymus, prostate, testis, and skeletal muscle and its levels are up regulated in certain cancers such as hepatocellular carcinoma.
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AKR1B10 protein (Human) (ab85415) |
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Database links
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The links below go to external sites and will open in a new browser window |
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Purity
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>95% by SDS-PAGE
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Storage buffer
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Preservative: None
Constituents: 10% Glycerol, 20mM Tris HCl, pH 8.0 Material safety datasheet (MSDS) for this product:
Glycerol MSDS
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Purification notes
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ab85415 is purified using conventional chromatography techniques.
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Form
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Liquid
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Concentration
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1.000 mg/ml
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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Expression system
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E. coli
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Sequence
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MATFVELSTK AKMPIVGLGT WKSPLGKVKE AVKVAIDAGY RHIDCAYVYQ NEHEVGEAIQ EKIQEKAVKR EDLFIVSKLW PTFFERPLVR KAFEKTLKDL KLSYLDVYLI HWPQGFKSGD DLFPKDDKGN AIGGKATFLD AWEAMEELVD EGLVKALGVS NFSHFQIEKL LNKPGLKYKP VTNQVECHPY LTQEKLIQYC HSKGITVTAY SPLGSPDRPW AKPEDPSLLE DPKIKEIAAK HKKTAAQVLI RFHIQRNVIV IPKSVTPARI VENIQVFDFK LSDEEMATIL SFNRNWRACN VLQSSHLEDY PFDAEY
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this AKR1B10 protein (Human) is on this datasheet. But please do contact us if you would like any reassurance! |
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See below for AKR1B10 protein (Human) images, references, products related to ab85415 and other tools.
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AKR1B10 protein (Human) images:
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 SDS-PAGE - AKR1B10 protein (Human) (ab85415)
15% SDS-PAGE showing ab85415 at approximately 36kDa (3µg).
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Search PubMed (MEDLINE) for references to AKR1B10
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AKR1B10 protein (Human) - more information
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Customer reviews (feedback) regarding AKR1B10 protein (Human) |
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