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Products:Signal Transduction >> Growth Factors/Hormones >> Hormones
Overview
Product name
Anti-AKR1C1 antibody
See all AKR1C1 products (4) ...
Description
Mouse polyclonal to AKR1C1
Tested applications
Cross reactivity
Reacts with
Human
Immunogen
Full length protein, corresponding to amino acids 1-323 of Human AKR1C1 (NP_001344.2)
Positive control
293T cells transfected with AKR1C1 Human liver tissue lysate
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: 1X PBS, pH 7.2
Concentration
Concentration information loading...
Purity
Protein A purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Developmental Biology >> Reproduction >> Hormones
Signal Transduction >> Metabolism >> Drug metabolism
Signal Transduction >> Metabolism >> Energy Metabolism
Signal Transduction >> Growth Factors/Hormones >> Hormones
Applications
Show applications key
Our Abpromise guarantee covers the use of ab72576 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: 1/500 - 1/1000.Detects a band of approximately 37 kDa (predicted molecular weight: 37 kDa).
Target
Function
Converts progesterone to its inactive form, 20-alpha-dihydroxyprogesterone (20-alpha-OHP). In the liver and intestine, may have a role in the transport of bile. May have a role in monitoring the intrahepatic bile acid concentration. Has a low bile-binding ability. May play a role in myelin formation.
Tissue specificity
Expressed in all tissues tested including liver, prostate, testis, adrenal gland, brain, uterus, mammary gland and keratinocytes. Highest levels found in liver, mammary gland and brain.
Sequence similarities
Belongs to the aldo/keto reductase family.
Cellular localization
Cytoplasm.
Target information above from: UniProt accessionQ04828
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- 2-dihydrobenzene-1 antibody
- 2-diol dehydrogenase antibody
- 20 alpha (3 alpha) hydroxysteroid dehydrogenase antibody
see all
Database links
- Entrez Gene: 1645 Human
- Omim: 600449 Human
- SwissProt: Q04828 Human
- Unigene: 460260 Human
Anti-AKR1C1 antibody images:
Western blot - AKR1C1 antibody (ab72576)
Anti-AKR1C1 antibody (ab72576) at 1/500 dilution + Human liver tissue lysate at 50 µg
Secondary
Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/5000 dilution
developed using the ECL technique
Predicted band size : 37 kDa
Observed band size : 37 kDa
Western blot - AKR1C1 antibody (ab72576)
All lanes : Anti-AKR1C1 antibody (ab72576) at 1/500 dilution
Lane 1 : AKR1C1 transfcted 293T cell lysate
Lane 2 : Non transfected 293T cell lysate
Lysates/proteins at 25 µg per lane.
Secondary
Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/5000 dilution
developed using the ECL technique
Predicted band size : 37 kDa
Observed band size : 37 kDa
References for Anti-AKR1C1 antibody (ab72576)
ab72576 has not yet been referenced specifically in any publications.
Publishing research using ab72576? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"