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Products:Signal Transduction >> Growth Factors/Hormones >> Hormones
Overview
Product name
Anti-AKR1C3 antibody [NP6.G6.A6]
See all AKR1C3 products (5) ...
Description
Mouse monoclonal [NP6.G6.A6] to AKR1C3
Specificity
This antibody recognizes AKR1C3 and does not cross react with AKR1C1, AKR1C2, and AKR1C4.
Tested applications
ELISA, WBmore details
Cross reactivity
Reacts with
Human
Immunogen
Full length native protein (purified) (Human)
Positive control
cytosolic fraction extract of A549 human lung carcinoma cell.
Properties
Form
Liquid
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 15mM Sodium Azide
Constituents: 0.01M PBS, pH 7.4
Concentration
Concentration information loading...
Purification notes
ab49680 is a purified IgG1
Clonality
Monoclonal
Clone number
NP6.G6.A6
Myeloma
Sp2/0
Isotype
IgG1
Research areas
Neuroscience >> Endocrine system >> Gonadotrophic axis
Signal Transduction >> Metabolism >> Energy Metabolism
Signal Transduction >> Growth Factors/Hormones >> Hormones
Applications
Show applications key
Our Abpromise guarantee covers the use of ab49680 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ELISA: Use at an assay dependent dilution.
WB: Use a concentration of 0.25 - 0.5 µg/ml.Predicted molecular weight: 36 kDa.
Target
Function
Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.
Tissue specificity
Expressed in many tissues including adrenal gland, brain, kidney, liver, lung, mammary gland, placenta, small intestine, colon, spleen, prostate and testis. The dominant HSD in prostate and mammary gland. In the prostate, higher levels in epithelial cells than in stromal cells. In the brain, expressed in medulla, spinal cord, frontotemporal lobes, thalamus, subthalamic nuclei and amygdala. Weaker expression in the hippocampus, substantia nigra and caudate.
Sequence similarities
Belongs to the aldo/keto reductase family.
Cellular localization
Cytoplasm.
Target information above from: UniProt accessionP42330
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- brain antibody
- 17 beta HSD 5 antibody
- 17 beta hydroxysteroid dehydrogenase type 5 antibody
see all
Database links
- Entrez Gene: 8644 Human
- Omim: 603966 Human
- SwissProt: P42330 Human
- Unigene: 78183 Human
References for Anti-AKR1C3 antibody [NP6.G6.A6] (ab49680)
ab49680 has not yet been referenced specifically in any publications.
Publishing research using ab49680? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"