AKR1C3 antibody [NP6.G6.A6] (ab49680)

Product Name 

AKR1C3 antibody [NP6.G6.A6]

Product type 

Primary antibodies

Description 

Mouse monoclonal [NP6.G6.A6] to AKR1C3

Immunogen 

Full length native protein (purified) (Human)

Reacts with 
(species key)

Hu

Specificity 

This antibody recognizes AKR1C3 and does not cross react with AKR1C1, AKR1C2, and AKR1C4.

Tested applications 
(see key)

ELISA, WB

Abreviews 

Customer reviews (see key)

Read about Abreviews

Application notes 
(see key)

Recommended dilutions
ELISA: Use at an assay dependent dilution.
WB: Use at a concentration of 0.25 - 0.5 µg/ml. Predicted molecular weight: 36 kDa.


Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Positive control 
(see definition)

cytosolic fraction extract of A549 human lung carcinoma cell.

Cellular localization 

Cytoplasmic

Research areas 

Neuroscience >> Endocrine system >> Gonadotrophic axis
Signal Transduction >> Metabolism >> Energy Metabolism
Signal Transduction >> Growth Factors/Hormones >> Hormones

Relevance 

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20 alpha hydroxy progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation.

Database links 

Raised in 

Mouse

Clonality 

Monoclonal

Clone number 

NP6.G6.A6

Myeloma 

Sp2/0

Isotype 

IgG1

Storage buffer 

Preservative: 15mM Sodium Azide
Constituents: 0.01M PBS, pH 7.4

Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS

Purification notes 

ab49680 is a purified IgG1

Form 

Liquid

Concentration 

2.200 mg/ml

Storage instructions 

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

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