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Overview

Properties

Applications

Our Abpromise guarantee covers the use of ab57993 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.

    • Target

    • FunctionEfficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7-alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4-cholesten-3-one can also act as substrates.
    • Tissue specificityHighly expressed in liver. Expressed in testis and weakly in colon.
    • Involvement in diseaseCongenital bile acid synthesis defect 2 (CBAS2) [MIM:235555]: A condition characterized by jaundice, intrahepatic cholestasis and hepatic failure. Patients with this liver disease show absence or low levels of chenodeoxycholic acid and cholic acid in plasma and urine. Note=The disease is caused by mutations affecting the gene represented in this entry.
    • Sequence similaritiesBelongs to the aldo/keto reductase family.
    • Cellular localizationCytoplasm.

      • Target information above from: UniProt accession P51857 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links
      • Alternative names
          3-oxo-5-beta-steroid 4-dehydrogenase antibody3o5bred antibodyAK1D1_HUMAN antibody
          AKR1D1 antibodyaldo keto reductase family 1 member D1 (delta 4 3 ketosteroid 5 beta reductase) antibodyAldo keto reductase family 1 member D1 antibodyAldo-keto reductase family 1 member D1 antibodyCBAS2 antibodyDelta(4) 3 ketosteroid 5 beta reductase antibodyDelta(4) 3 oxosteroid 5 beta reductase antibodyDelta(4)-3-ketosteroid 5-beta-reductase antibodyDelta(4)-3-oxosteroid 5-beta-reductase antibodySRD5B1 antibodysteroid 5 beta reductase beta polypeptide 1 (3 oxo 5 beta steroid delta 4 dehydrogenase beta 1) antibodysteroid 5 beta reductase antibody
        see all

      Anti-AKR1D1 antibody images

      • Western blot - AKR1D1 antibody (ab57993)
        Western blot - AKR1D1 antibody (ab57993)
        Western blot against tagged recombinant protein immunogen using ab57993 AKR1D1 antibody at 1ug/ml. Predicted band size of immunogen is 34 kDa

      References for Anti-AKR1D1 antibody (ab57993)

      ab57993 has not yet been referenced specifically in any publications.

      Publishing research using ab57993 ? Please let us know so that we can cite the reference in this datasheet

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