AKT1 peptide - unmodified (ab24649)
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
- AKTAKT 1AKT1
- AKT1_HUMANC AKTCAKTMGC9965MGC99656Oncogene AKT1PKBPKB-ALPHAPRKBAProtein kinase BProtein Kinase B AlphaProto-oncogene c-AktRACRAC AlphaRAC alpha serine/threonine protein kinaseRAC PK AlphaRac protein kinase alphaRAC Serine/Threonine Protein KinaseRAC-alpha serine/threonine-protein kinaseRAC-PK-alphav akt murine thymoma viral oncogene homolog 1vAKT Murine Thymoma Viral Oncogene Homolog 1
Defects in AKT1 are associated with colorectal cancer (CRC) [MIM:114500].
Defects in AKT1 are associated with susceptibility to ovarian cancer [MIM:604370]; also called susceptibility to familial breast-ovarian cancer type 1 (BROVCA1).
Contains 1 AGC-kinase C-terminal domain.
Contains 1 PH domain.
Contains 1 protein kinase domain.
The AGC-kinase C-terminal mediates interaction with THEM4.
modificationsPhosphorylation on Thr-308, Ser-473 and Tyr-474 is required for full activity. Activated TNK2 phosphorylates it on Tyr-176 resulting in its binding to the anionic plasma membrane phospholipid PA. This phosphorylated form localizes to the cell membrane, where it is targeted by PDPK1 and PDPK2 for further phosphorylations on Thr-308 and Ser-473 leading to its activation. Ser-473 phosphorylation by mTORC2 favors Thr-308 phosphorylation by PDPK1. Ser-473 phosphorylation is enhanced by interaction with AGAP2 isoform 2 (PIKE-A). Ser-473 phosphorylation is enhanced in focal cortical dysplasias with Taylor-type balloon cells.
Ubiquitinated; undergoes both 'Lys-48'- and 'Lys-63'-linked polyubiquitination. TRAF6-induced 'Lys-63'-linked AKT1 ubiquitination is critical for phosphorylation and activation. When ubiquitinated, it translocates to the plasma membrane, where it becomes phosphorylated. When fully phosphorylated and translocated into the nucleus, undergoes 'Lys-48'-polyubiquitination catalyzed by TTC3, leading to its degradation by the proteasome.
References for AKT1 peptide - unmodified (ab24649)
ab24649 has not yet been referenced specifically in any publications.