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Overview

Properties

Applications

Our Abpromise guarantee covers the use of ab13922 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB
  • Application notesWB: Use at a concentration of 1 - 2 µg/ml. Predicted molecular weight: 56 kDa. Ab13922 can be used for detection of AKT3 in human, mouse and rat by western blot analysis.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.

    • Target

    • FunctionIGF-1 leads to the activation of AKT3, which may play a role in regulating cell survival. Capable of phosphorylating several known proteins. Truncated isoform 2/PKB gamma 1 without the second serine phosphorylation site could still be stimulated but to a lesser extent.
    • Tissue specificityIn adult tissues, it is highly expressed in brain, lung and kidney, but weakly in heart, testis and liver. In fetal tissues, it is highly expressed in heart, liver and brain and not at all in kidney.
    • Sequence similaritiesBelongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.
      Contains 1 AGC-kinase C-terminal domain.
      Contains 1 PH domain.
      Contains 1 protein kinase domain.
    • DomainBinding of the PH domain to the phosphatidylinositol 3-kinase alpha (PI(3)K) results in its targeting to the plasma membrane.
    • Post-translational
      modifications      Phosphorylation on Thr-305 and Ser-472 is required for full activity (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR.
      Ubiquitinated. When fully phosphorylated and translocated into the nucleus, undergoes 'Lys-48'-polyubiquitination catalyzed by TTC3, leading to its degradation by the proteasome.
    • Cellular localizationCytoplasm. Membrane. Membrane-associated after cell stimulation leading to its translocation.

      • Target information above from: UniProt accession Q9Y243 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links
      see all
    • Alternative names
        Akt3 antibodyAKT3 kinase antibodyAKT3_HUMAN antibody
        DKFZP434N0250 antibodyPKB Gamma antibodyPKBG antibodyPRKBG antibodyProtein kinase Akt-3 antibodyProtein Kinase AKT3 antibodyProtein Kinase B Gamma antibodyRAC gamma antibodyRAC Gamma Serine/Threonine Protein Kinase antibodyRAC-gamma serine/threonine-protein kinase antibodyRAC-PK-gamma antibodyRACPK Gamma antibodySerine threonine protein kinase Akt 3 antibodySerine Threonine Protein Kinase AKT3 antibodySTK 2 antibodySTK-2 antibodySTK2 antibodyV akt murine thymoma viral oncogene homolog 3 protein kinase B gamma antibodyVAKT Murine Thymoma Viral Oncogene Homolog 3 antibody
      see all

    References for Anti-AKT3 antibody (ab13922)

    ab13922 has not yet been referenced specifically in any publications.

    Publishing research using ab13922 ? Please let us know so that we can cite the reference in this datasheet

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