ALAS2 protein (His tag) (ab79941)

Product Name 

ALAS2 protein (His tag)

Product type 

Proteins and Peptides

Peptide 

Recombinant fragment corresponding to amino acids 136-553 of Human ALAS2 with N terminal His tag, 46 kDa. Swiss ID = P22557

Tested applications 
(see key)

SDS-PAGE

Application notes 
(see key)

Recommended dilutions
SDS-PAGE: Use at an assay dependent dilution.

ab79941 is useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Research areas 

Cancer >> Cancer Metabolism >> Response to hypoxia
Cardiovascular >> Blood >> Erythrocytes
Signal Transduction >> Metabolism >> Mitochondrial
Signal Transduction >> Metabolism >> Amino Acids
Cardiovascular >> Hypoxia >> Hypoxia-Regulated

Relevance 

ALAS2 specifies an erythroid-specific mitochondrially located enzyme. It catalyzes the first step in the heme biosynthetic pathway. Defects in this gene cause X-linked pyridoxine-responsive sideroblastic anemia. Alternatively spliced transcript variants encoding different isoforms have been identified.

Purity 

>90% by SDS-PAGE

Storage buffer 

Preservative: None
Constituents: 20% Glycerol, 0.05% Tween 20, 3mM DTT, 25mM Tris HCl, 100mM Sodium chloride, 20 µM pyridoxal 5' phosphate monohydrate pH 8.0

Material safety datasheet (MSDS) for this product:
Glycerol MSDS

Form 

Liquid

Storage instructions 

Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.

Expression system 

E. coli

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