Anti-ALDH5A1 antibody (ab106823)

Overview

• Product nameAnti-ALDH5A1 antibodySee all ALDH5A1 primary antibodies ...
• Description
  Goat polyclonal to ALDH5A1
• SpecificityThis antibody is expected to recognize both reported isoforms (NP_733936.1; NP_001071.1)
• Tested applicationsWB more details
• Species reactivity
  Reacts with: Mouse, Rat, Human
  Predicted to work with: Cow, Dog, Chimpanzee
• Immunogen

  Synthetic peptide: SQDPAQIWRVAE by a Cysteine residue linker, corresponding to internal sequence amino acids 472-483 of Human ALDH5A1 (NP_733936.1; NP_001071.1)

  Run BLAST with Run BLAST with
• Positive controlHuman, Mouse and Rat Liver lysate

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Storage bufferPreservative: 0.02% Sodium Azide
  Constituents: 0.5% BSA, Tris buffered saline, pH 7.3
• Concentration information loading...
• PurityImmunogen affinity purified
• Purification notesPurified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Metabolism
  • Pathways and Processes
  • Mitochondrial Metabolism
  • Mitochondrial markers

  • Metabolism
  • Types of disease
  • Cancer

  • Metabolism
  • Pathways and Processes
  • Metabolic signaling pathways
  • Amino acid metabolism

  • Signal Transduction
  • Metabolism
  • Lipid metabolism

  • Signal Transduction
  • Metabolism
  • Mitochondrial

  • Neuroscience
  • Neurotransmitter
  • Amino Acids
  • GABA

Applications

Target

• FunctionCatalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).
• Tissue specificityBrain, pancreas, heart, liver, skeletal muscle and kidney. Lower in placenta.
• PathwayAmino-acid degradation; 4-aminobutanoate degradation.
• Involvement in diseaseDefects in ALDH5A1 are the cause of succinate semialdehyde dehydrogenase deficiency (SSADH deficiency) [MIM:271980]. SSADH deficiency is a rare inborn error in the metabolism of 4-aminobutyric acid (GABA) which leads to accumulation of 4-hydroxybutyric acid in physiologic fluids of patients. The disease is characterized by severe ataxia and by mildly retarded psychomotor development.
• Sequence similaritiesBelongs to the aldehyde dehydrogenase family.
• Cellular localizationMitochondrion.

Target information above from: UniProt accession P51649 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 532724 Cow
  • Entrez Gene: 7915 Human
  • Entrez Gene: 214579 Mouse
  • Entrez Gene: 291133 Rat
  • Omim: 610045 Human
  • SwissProt: P51649 Human
  • SwissProt: Q8BWF0 Mouse
  • SwissProt: P51650 Rat

  • Unigene: 371723 Human
  • Unigene: 393311 Mouse
  • Unigene: 10070 Rat

  see all

• Alternative names
  Aldedehyde dehydrogenase 5 family antibodyAldehyde dehydrogenase 5 family member A1 antibodyAldehyde dehydrogenase 5A1 antibody

  Aldehyde dehydrogenase family 5 member A1 antibodyALDH5A 1 antibodyAldh5a1 antibodymitochondrial antibodyMitochondrial succinate semialdehyde dehydrogenase antibodyNAD(+) dependent succinic semialdehyde dehydrogenase antibodyNAD(+)-dependent succinic semialdehyde dehydrogenase antibodySSADH antibodySSDH antibodySSDH_HUMAN antibodySuccinate semialdehyde dehydrogenase antibodySuccinate-semialdehyde dehydrogenase antibody

  see all

Anti-ALDH5A1 antibody images

• 

  Western blot - ALDH5A1 antibody (ab106823)
  Anti-ALDH5A1 antibody (ab106823) at 0.5 µg/ml + Human Liver lysate at 35 µg
  developed using the ECL technique
  
  Predicted band size : 57 kDa