Overview

  • Product nameAnti-ALDH5A1 antibodySee all ALDH5A1 primary antibodies ...
  • Description
    Goat polyclonal to ALDH5A1
  • SpecificityThis antibody is expected to recognize both reported isoforms (NP_733936.1; NP_001071.1)
  • Tested applicationsWB, IHC-P more details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
    Predicted to work with: Cow, Dog, Chimpanzee
  • Immunogen

    Synthetic peptide: SQDPAQIWRVAE by a Cysteine residue linker, corresponding to internal sequence amino acids 472-483 of Human ALDH5A1 (NP_733936.1; NP_001071.1)

  • Positive control
    • Human, Mouse and Rat Liver lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab106823 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB Use a concentration of 0.3 - 1 µg/ml. Predicted molecular weight: 57 kDa.
IHC-P Use a concentration of 5 - 10 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • FunctionCatalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).
  • Tissue specificityBrain, pancreas, heart, liver, skeletal muscle and kidney. Lower in placenta.
  • PathwayAmino-acid degradation; 4-aminobutanoate degradation.
  • Involvement in diseaseDefects in ALDH5A1 are the cause of succinate semialdehyde dehydrogenase deficiency (SSADH deficiency) [MIM:271980]. SSADH deficiency is a rare inborn error in the metabolism of 4-aminobutyric acid (GABA) which leads to accumulation of 4-hydroxybutyric acid in physiologic fluids of patients. The disease is characterized by severe ataxia and by mildly retarded psychomotor development.
  • Sequence similaritiesBelongs to the aldehyde dehydrogenase family.
  • Cellular localizationMitochondrion.
  • Target information above from: UniProt accession P51649 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
  • Alternative names
    • Aldedehyde dehydrogenase 5 family antibody
    • Aldehyde dehydrogenase 5 family member A1 antibody
    • Aldehyde dehydrogenase 5A1 antibody
    • Aldehyde dehydrogenase family 5 member A1 antibody
    • ALDH5A 1 antibody
    • Aldh5a1 antibody
    • mitochondrial antibody
    • Mitochondrial succinate semialdehyde dehydrogenase antibody
    • NAD(+) dependent succinic semialdehyde dehydrogenase antibody
    • NAD(+)-dependent succinic semialdehyde dehydrogenase antibody
    • SSADH antibody
    • SSDH antibody
    • SSDH_HUMAN antibody
    • Succinate semialdehyde dehydrogenase antibody
    • Succinate-semialdehyde dehydrogenase antibody
    see all

Anti-ALDH5A1 antibody images

  • ab106823 (5µg/ml) shows staining of ALDH5A1 in paraffin embedded Human Liver following steamed antigen retrieval with citrate buffer pH 6 and AP-staining. This shows heavy textured cystoplasm staining in hepatocytes, consistent with mitochondia.

  • Anti-ALDH5A1 antibody (ab106823) at 0.5 µg/ml + Human Liver lysate at 35 µg
    developed using the ECL technique

    Predicted band size : 57 kDa

References for Anti-ALDH5A1 antibody (ab106823)

ab106823 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab106823.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"