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Overview

  • Product nameAnti-ALDH5A1 antibodySee all ALDH5A1 primary antibodies ...
  • Description
    Rabbit polyclonal to ALDH5A1
  • Tested applicationsWB, ELISA more details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic 22 amino acid peptide from near the C terminus of Human ALDH5A1 (NP_733936).

  • Positive controlMouse liver tissue lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab77078 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB WB: Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 57 kDa.
ELISA ELISA: Use at an assay dependent dilution.

Target

  • FunctionCatalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).
  • Tissue specificityBrain, pancreas, heart, liver, skeletal muscle and kidney. Lower in placenta.
  • PathwayAmino-acid degradation; 4-aminobutanoate degradation.
  • Involvement in diseaseDefects in ALDH5A1 are the cause of succinate semialdehyde dehydrogenase deficiency (SSADH deficiency) [MIM:271980]. SSADH deficiency is a rare inborn error in the metabolism of 4-aminobutyric acid (GABA) which leads to accumulation of 4-hydroxybutyric acid in physiologic fluids of patients. The disease is characterized by severe ataxia and by mildly retarded psychomotor development.
  • Sequence similaritiesBelongs to the aldehyde dehydrogenase family.
  • Cellular localizationMitochondrion.

    • Target information above from: UniProt accession P51649 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
    see all
  • Alternative names
      Aldedehyde dehydrogenase 5 family antibodyAldehyde dehydrogenase 5 family member A1 antibodyAldehyde dehydrogenase 5A1 antibody
      Aldehyde dehydrogenase family 5 member A1 antibodyALDH5A 1 antibodyAldh5a1 antibodymitochondrial antibodyMitochondrial succinate semialdehyde dehydrogenase antibodyNAD(+) dependent succinic semialdehyde dehydrogenase antibodyNAD(+)-dependent succinic semialdehyde dehydrogenase antibodyOTTHUMP00000016088 antibodySSADH antibodySSDH antibodySSDH_HUMAN antibodySuccinate semialdehyde dehydrogenase antibodySuccinate-semialdehyde dehydrogenase antibody
    see all

Anti-ALDH5A1 antibody images

  • Western blot - ALDH5A1 antibody (ab77078)
    Western blot - ALDH5A1 antibody (ab77078)
    Lane 1 : Anti-ALDH5A1 antibody (ab77078) at 1 µg/ml
    Lane 2 : Anti-ALDH5A1 antibody (ab77078) at 2 µg/ml

    Lane 1 : Mouse liver lysate
    Lane 2 : Mouse liver lysate

    Lysates/proteins at 15 µg per lane.


    Predicted band size : 57 kDa
    Observed band size : 57 kDa
    Additional bands at : 60 kDa,>90 kDa. We are unsure as to the identity of these extra bands.

References for Anti-ALDH5A1 antibody (ab77078)

ab77078 has not yet been referenced specifically in any publications.

Publishing research using ab77078 ? Please let us know so that we can cite the reference in this datasheet

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