Overview

  • Product nameAnti-ALDH5A1 antibodySee all ALDH5A1 primary antibodies ...
  • Description
    Rabbit polyclonal to ALDH5A1
  • Tested applicationsWB, ELISA more details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic 22 amino acid peptide from near the C terminus of Human ALDH5A1 (NP_733936).

  • Positive control
    • Mouse liver tissue lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab77078 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 57 kDa.
ELISA Use at an assay dependent dilution.

Target

  • FunctionCatalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).
  • Tissue specificityBrain, pancreas, heart, liver, skeletal muscle and kidney. Lower in placenta.
  • PathwayAmino-acid degradation; 4-aminobutanoate degradation.
  • Involvement in diseaseDefects in ALDH5A1 are the cause of succinate semialdehyde dehydrogenase deficiency (SSADH deficiency) [MIM:271980]. SSADH deficiency is a rare inborn error in the metabolism of 4-aminobutyric acid (GABA) which leads to accumulation of 4-hydroxybutyric acid in physiologic fluids of patients. The disease is characterized by severe ataxia and by mildly retarded psychomotor development.
  • Sequence similaritiesBelongs to the aldehyde dehydrogenase family.
  • Cellular localizationMitochondrion.
  • Target information above from: UniProt accession P51649 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
  • Alternative names
    • Aldedehyde dehydrogenase 5 family antibody
    • Aldehyde dehydrogenase 5 family member A1 antibody
    • Aldehyde dehydrogenase 5A1 antibody
    • Aldehyde dehydrogenase family 5 member A1 antibody
    • ALDH5A 1 antibody
    • Aldh5a1 antibody
    • mitochondrial antibody
    • Mitochondrial succinate semialdehyde dehydrogenase antibody
    • NAD(+) dependent succinic semialdehyde dehydrogenase antibody
    • NAD(+)-dependent succinic semialdehyde dehydrogenase antibody
    • OTTHUMP00000016088 antibody
    • SSADH antibody
    • SSDH antibody
    • SSDH_HUMAN antibody
    • Succinate semialdehyde dehydrogenase antibody
    • Succinate-semialdehyde dehydrogenase antibody
    see all

Anti-ALDH5A1 antibody images

  • Lane 1 : Anti-ALDH5A1 antibody (ab77078) at 1 µg/ml
    Lane 2 : Anti-ALDH5A1 antibody (ab77078) at 2 µg/ml

    Lane 1 : Mouse liver lysate
    Lane 2 : Mouse liver lysate

    Lysates/proteins at 15 µg per lane.


    Predicted band size : 57 kDa
    Observed band size : 57 kDa
    Additional bands at : 60 kDa,>90 kDa. We are unsure as to the identity of these extra bands.

References for Anti-ALDH5A1 antibody (ab77078)

ab77078 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab77078.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"