Anti-ALK (phospho Y1096) antibody (ab111865)

Overview

  • Product nameAnti-ALK (phospho Y1096) antibody
    See all ALK primary antibodies
  • Description
    Rabbit polyclonal to ALK (phospho Y1096)
  • Specificityab111865 detects endogenous levels of ALK only when phosphorylated at tyrosine 1096.
  • Tested applicationsIHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic phosphopeptide derived from Human ALK around the phosphorylation site of tyrosine 1096 (P-N-YP-C-F).

  • Positive control
    • Human breast carcinoma tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab111865 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • FunctionOrphan receptor with a tyrosine-protein kinase activity. Appears to play an important role in the normal development and function of the nervous system. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif.
  • Tissue specificityExpressed in brain and CNS. Also expressed in the small intestine and testis, but not in normal lymphoid cells.
  • Involvement in diseaseNote=A chromosomal aberration involving ALK is found in a form of non-Hodgkin lymphoma. Translocation t(2;5)(p23;q35) with NPM1. The resulting chimeric NPM1-ALK protein homodimerize and the kinase becomes constitutively activated. The constitutively active fusion proteins are responsible for 5-10% of non-Hodgkin lymphomas.
    Note=A chromosomal aberration involving ALK is associated with inflammatory myofibroblastic tumors (IMTs). Translocation t(2;11)(p23;p15) with CARS; translocation t(2;4)(p23;q21) with SEC31A.
    Note=A chromosomal aberration involving ALK is associated with anaplastic large-cell lymphoma (ALCL). Translocation t(2;17)(p23;q25) with ALO17.
    Defects in ALK are the cause of susceptibility to neuroblastoma type 3 (NBLST3) [MIM:613014]. Neuroblastoma is a common neoplasm of early childhood arising from embryonic cells that form the primitive neural crest and give rise to the adrenal medulla and the sympathetic nervous system.
  • Sequence similaritiesBelongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
    Contains 1 LDL-receptor class A domain.
    Contains 2 MAM domains.
    Contains 1 protein kinase domain.
  • Post-translational
    modifications
    N-glycosylated.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Alk antibody
    • ALK tyrosine kinase receptor antibody
    • ALK/EML4 fusion gene, included antibody
    • ALK/NPM1 fusion gene, included antibody
    • ALK_HUMAN antibody
    • anaplastic lymphoma kinase (Ki-1) antibody
    • Anaplastic lymphoma kinase antibody
    • Anaplastic lymphoma kinase Ki1 antibody
    • anaplastic lymphoma receptor tyrosine kinase antibody
    • CD 246 antibody
    • CD246 antibody
    • CD246 antigen antibody
    • EC 2.7.10.1 antibody
    • Ki 1 antibody
    • Ki1 antibody
    • mutant anaplastic lymphoma kinase antibody
    • NBLST 3 antibody
    • NBLST3 antibody
    • Tcrz antibody
    • TFG/ALK antibody
    see all

Anti-ALK (phospho Y1096) antibody images

  • ab111865 at 1/50 dilution staining ALK in paraffin-embedded Human Brain tissue by Immunohistochemistry. The image on the right is treated with the synthesized phosphopeptide.

References for Anti-ALK (phospho Y1096) antibody (ab111865)

ab111865 has not yet been referenced specifically in any publications.

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