Anti-ALS2CR2 antibody (ab4122)

Overview

• Product nameAnti-ALS2CR2 antibodySee all ALS2CR2 primary antibodies ...
• Description
  Goat polyclonal to ALS2CR2
• SpecificityThis is expected to recognise both human isoforms: ILPIP alpha (NP_061041) and ILPIP beta (AAF71042).
• Tested applicationsIHC-P, WB more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  Synthetic peptide: CDFPDEKDSYWEF, corresponding to amino acids 406-418 of Human ALS2CR2.

  Run BLAST with Run BLAST with
• Positive controlHuman heart or liver lysate.

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Storage bufferPreservative: 0.02% Sodium Azide
  Constituents: 0.5% BSA, Tris buffered saline, pH 7.3
• Concentration information loading...
• PurityImmunogen affinity purified
• Purification notesPurified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Metabolism
  • Pathways and Processes
  • Metabolic signaling pathways
  • Energy transfer pathways
  • Integration of energy

  • Metabolism
  • Types of disease
  • Neurodegenerative disease

  • Metabolism
  • Types of disease
  • Cancer

  • Cancer
  • Cancer Metabolism
  • Metabolic signaling pathway
  • Integration of energy metabolism

  • Neuroscience
  • Neurology process
  • Neurodegenerative disease
  • Other

  • Neuroscience
  • Neurology process
  • Neurodegenerative disease
  • Alzheimer's disease
  • Other

Applications

Target

• FunctionPseudokinase which, in complex with CAB39, binds to and activates STK11. Relocates STK11 from the nucleus to the cytoplasm. Plays an essential role in STK11-mediated G1 cell cycle arrest.
• Tissue specificityHighly expressed in heart, skeletal muscle, testis, liver and colon.
• Sequence similaritiesBelongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
  Contains 1 protein kinase domain.
• DomainThe protein kinase domain is predicted to be catalytically inactive.
• Cellular localizationNucleus. Cytoplasm.

Target information above from: UniProt accession Q9C0K7 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 55437 Human
  • Entrez Gene: 55437 Human
  • Entrez Gene: 55437 Human
  • Entrez Gene: 55437 Human
  • Omim: 607333 Human
  • SwissProt: Q9C0K7 Human
  • SwissProt: Q9C0K7 Human
  • SwissProt: Q9C0K7 Human

  • SwissProt: Q9C0K7 Human
  • Unigene: 652338 Human

  see all

• Alternative names
  Amyotrophic lateral sclerosis 2 (juvenile) chromosome region candidate 2 antibodyAmyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein antibodyCALS 21 antibody

  CALS-21 antibodyILP interacting protein ILPIPA antibodyILP-interacting protein antibodyILPIP antibodyILPIPA antibodyLikely ortholog of mouse polyploidy associated protein kinase antibodyPAPK antibodyPRO1038 antibodyPseudokinase ALS2CR2 antibodySTE20-related kinase adapter protein beta antibodySTRAB_HUMAN antibodySTRAD beta antibodySTRADB antibody

  see all

Anti-ALS2CR2 antibody images

• 

  Western blot - ALS2CR2 antibody (ab4122)
  
  
  Predicted band size : 47 kDa
  
  
  ab4122 at a concentration of 1µg/ml staining ALS2CR2 in human heart lysate (RIPA buffer, 30µg total protein per lane) by Western blot. Primary incubated for 1 hour and detected by chemiluminescence.
• 

  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - ALS2CR2 antibody (ab4122)
  ab4122 (3.8 µg/ml) staining ALS2CR2 in myocardial fibers in a transverse section of paraffin-embedded human heart following steamed antigen retrieval with citrate buffer pH6.