AMACR antibody (ab15893)

Product Name 

AMACR antibody

Product type 

Primary antibodies

Description 

Rabbit polyclonal to AMACR

Immunogen 

Synthetic peptide: GAAVLRRLCKRSDVLLEPFR , corresponding to amino acids 62-81 of Human AMCR.
BLAST 'GAAVLRRLCKRSDVLLEPFR' with or

Reacts with 
(species key)

Hu, Ms, Rat

Epitope 

ab15893 recognises a unique epitope that is present on AMCR I and II variants

Tested applications 
(see key)

IM, WB

Abreviews 

Customer reviews (see key)

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Application notes 
(see key)

Recommended dilutions
IM: Use at an assay dependent dilution.
WB: 1/500. Ab15893 strongly labels bands at 32 and 42 kDa corresponding to AMCR I and II variants.

Does not work well with IHC.

Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Cellular localization 

Mitochondrial and Peroxisomal.

Research areas 

Cancer >> Cancer Metabolism >> Metabolic signaling pathway >> Metabolism of lipids and lipoproteins
Cell Biology >> Other Antibodies >> Oxidative Stress
Signal Transduction >> Metabolism >> Lipid metabolism
Chromatin and Nuclear Signaling >> Transcription >> Cancer susceptibility >> Proto-oncogenes
Signal Transduction >> Metabolism >> Mitochondrial
Tags & Cell Markers >> Cell Type Markers >> Tumor Associated

Relevance 

AMARC has been recently described as prostate cancer-specific gene that encodes a protein involved in the beta-oxidation of branched chain fatty acids. Expression of AMARC protein is found in prostatic adenocarcinoma but not in benign prostatic tissue. It stains premalignant lesions of prostate: high-grade prostatic intraepithelial neoplasia (PIN) and atypical adenomatous hyperplasia.

Database links 

Raised in 

Rabbit

Clonality 

Polyclonal

Isotype 

IgG

Purity 

Immunogen affinity purified

Form 

Liquid

Concentration 

0.660 mg/ml

Storage instructions 

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

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