AMACR antibody (ab15894)

Product Name 

AMACR antibody

Product type 

Primary antibodies

Description 

Rabbit polyclonal to AMACR

Immunogen 

Synthetic peptide: TDACVTPVLTFEEWHHD, corresponding to amino acids 290-307 of Human AMACR
BLAST 'TDACVTPVLTFEEWHHD' with or

Reacts with 
(species key)

Hu, Ms

Specificity 

Ab15894 is specific for AMCR I

Tested applications 
(see key)

IM, WB

Abreviews 

Customer reviews (see key)

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Application notes 
(see key)

Recommended dilutions
IM: Use at an assay dependent dilution.
WB: 1/500. Predicted molecular weight: 42 kDa corresponding to variant AMCR I.

Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Cellular localization 

Mitochondrial and Peroxisomal.

Research areas 

Cancer >> Cancer Metabolism >> Metabolic signaling pathway >> Metabolism of lipids and lipoproteins
Cell Biology >> Other Antibodies >> Oxidative Stress
Signal Transduction >> Metabolism >> Lipid metabolism
Chromatin and Nuclear Signaling >> Transcription >> Cancer susceptibility >> Proto-oncogenes
Signal Transduction >> Metabolism >> Mitochondrial
Tags & Cell Markers >> Cell Type Markers >> Tumor Associated

Relevance 

AMARC has been recently described as prostate cancer-specific gene that encodes a protein involved in the beta-oxidation of branched chain fatty acids. Expression of AMARC protein is found in prostatic adenocarcinoma but not in benign prostatic tissue. It stains premalignant lesions of prostate: high-grade prostatic intraepithelial neoplasia (PIN) and atypical adenomatous hyperplasia.

Database links 

Raised in 

Rabbit

Clonality 

Polyclonal

Isotype 

IgG

Purity 

Immunogen affinity purified

Storage buffer 

Preservative: None
Constituents: BSA

Purification notes 

Affinity purified against immobilized antigen. Supplied as a pure IgG fraction.

Form 

Liquid

Concentration 

0.750 mg/ml

Storage instructions 

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

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