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Products:Cell Biology >> Proteolysis / Ubiquitin >> Proteasome / Ubiquitin >> Ubiquitin E2s and E3s >> RING Finger E3 Ligase
Overview
Product name
Anti-AMFR antibody - Aminoterminal end
See all AMFR products (5) ...
Description
Rabbit polyclonal to AMFR - Aminoterminal end
Tested applications
WB, ELISAmore details
Cross reactivity
Reacts with
Recombinant Fragment
Predicted to work with
Mouse, Human
Immunogen
Synthetic peptide corresponding to N-terminal residues of human AMFR (Autocrine motility factor receptor, isoform 2).
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
Preservative: 0.01% Sodium Azide
Constituents: 50% Glycerol, PBS
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Cancer >> Tumor biomarkers >> Other
Cell Biology >> Proteolysis / Ubiquitin >> Proteasome / Ubiquitin >> Ubiquitin E2s and E3s >> RING Finger E3 Ligase
Applications
Show applications key
Our Abpromise guarantee covers the use of ab54516 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use a concentration of 1 µg/mlPredicted molecular weight: 34 kDa.(This antibody has been tested in Western blot against the recombinant peptide used as an immunogen. We have no data on detection of endogenous protein.)
ELISA: Use at an assay dependent dilution.
Target
Function
E3 ubiquitin-protein ligase which can target both itself and other proteins including CD3D and APOB for proteasomal degradation. Mediates polyubiquitination of CYP3A4. Specific receptor for the autocrine motility factor. Mediates tumor invasion and metastasis. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulun that are retrotranslocated in the cytosol. Promotes ubiquitination of misfolded proteins such as mutant CFTR; proposed to mediate sequential ubiquitination by recognizing already ubiquitin-conjugated substrates and to cooperate with E3 ubiquitin-protein ligase RNF5.
Pathway
Protein modification; protein ubiquitination.
Sequence similarities
Contains 1 CUE domain.
Contains 1 RING-type zinc finger.
Cellular localization
Endoplasmic reticulum membrane.
Target information above from: UniProt accessionQ9UKV5
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- isoform 2 antibody
- AMF receptor antibody
- AMF receptor isoform 1 antibody
see all
Database links
- Entrez Gene: 267 Human
- Entrez Gene: 23802 Mouse
- Omim: 603243 Human
- SwissProt: P26442 Human
- SwissProt: Q9UKV5 Human
- SwissProt: Q9R049 Mouse
- Unigene: 295137 Human
- Unigene: 34641 Mouse
References for Anti-AMFR antibody - Aminoterminal end (ab54516)
ab54516 has not yet been referenced specifically in any publications.
Publishing research using ab54516? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"