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Anti-AMFR antibody (ab76841)

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Overview

Product name

Anti-AMFR antibody
See all AMFR products (5) ...

Description

Rabbit polyclonal to AMFR

Specificity

ab76841 reacts specifically with the 73 kda (isoform 2) protein.

Tested applications

WB, IHC-P, IHC-Frmore details

Cross reactivity

Reacts with

Human

Predicted to work with

Mouse

Immunogen

Synthetic peptide derived from the C terminal domain of human AMFR protein.

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: None
Constituents: Whole serum

Purity

Whole antiserum

Clonality

Polyclonal

Isotype

IgG

Research areas

Cancer >> Tumor biomarkers >> Other
Cell Biology >> Proteolysis / Ubiquitin >> Proteasome / Ubiquitin >> Ubiquitin E2s and E3s >> RING Finger E3 Ligase

Applications

Show applications key

Our Abpromise guarantee covers the use of ab76841 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • ShowHide

    WB

     WB: 1/100 - 1/1000.Predi...Read more →

    WB: 1/100 - 1/1000.Predicted molecular weight: 34,73 kDa.

  • IHC-P

     IHC-P: 1/50 - 1/200.

    IHC-P: 1/50 - 1/200.

  • IHC-Fr

     IHC-Fr: 1/50 - 1/200.

    IHC-Fr: 1/50 - 1/200.

Target

Function

E3 ubiquitin-protein ligase which can target both itself and other proteins including CD3D and APOB for proteasomal degradation. Mediates polyubiquitination of CYP3A4. Specific receptor for the autocrine motility factor. Mediates tumor invasion and metastasis. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulun that are retrotranslocated in the cytosol. Promotes ubiquitination of misfolded proteins such as mutant CFTR; proposed to mediate sequential ubiquitination by recognizing already ubiquitin-conjugated substrates and to cooperate with E3 ubiquitin-protein ligase RNF5.

Pathway

Protein modification; protein ubiquitination.

Sequence similarities

Contains 1 CUE domain.
Contains 1 RING-type zinc finger.

Cellular localization

Endoplasmic reticulum membrane.

Target information above from: UniProt accessionQ9UKV5 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • isoform 2 antibody
  • AMF receptor antibody
  • AMF receptor isoform 1 antibody
  • AMF receptor isoform 2 antibody
  • AMFR antibody
  • AMFR2_HUMAN antibody
  • Autocrine motility factor receptor antibody
  • Autocrine motility factor receptor precursor, isoform 1 antibody
  • Autocrine motility factor receptor precursor, isoform 2 antibody
  • E3 ubiquitin-protein ligase AMFR antibody
  • gp78 antibody
  • RING finger protein 45 antibody
  • RNF 45 antibody
  • RNF45 antibody
see all

Database links

References for Anti-AMFR antibody (ab76841)

ab76841 has not yet been referenced specifically in any publications.

Publishing research using ab76841? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"