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Products:Signal Transduction >> Protein Phosphorylation >> Ser / Thr Kinases >> Other Kinases
Overview
Product name
Anti-AMHR2 antibody - Aminoterminal end
See all AMHR2 products (3) ...
Description
Rabbit polyclonal to AMHR2 - Aminoterminal end
Tested applications
WB, ELISAmore details
Cross reactivity
Reacts with
Human
Immunogen
KLH conjugated synthetic peptide selected from the N terminal region of human AMHR2.
Positive control
Transfected 293 cell lysates.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
Preservative: 0.09% Sodium Azide
Constituents: PBS
Concentration
Concentration information loading...
Purity
Ammonium Sulphate Precipitation
Purification notes
This antibody is prepared by Saturated Ammonium Sulfate precipitation followed by dialysis against PBS.
Clonality
Polyclonal
Isotype
IgG
Research areas
Stem Cells >> Signaling Pathways >> TGF beta >> Surface Molecules
Signal Transduction >> Growth Factors/Hormones >> TGF
Signal Transduction >> Protein Phosphorylation >> Ser / Thr Kinases >> Other Kinases
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Western blot - AMHR2 antibody - Aminoterminal end (ab75845)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab75845 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: 1/50 - 1/100.Predicted molecular weight: 63 kDa.
ELISA
ELISA: 1/1000ELISA: 1/1000
Target
Function
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.
Involvement in disease
Defects in AMHR2 are the cause of persistent Muellerian duct syndrome type 2 (PMDS2) [MIM:261550]. PMDS2 is a form of male pseudohermaphroditism characterized by a failure of Muellerian duct regression in otherwise normal males.
Sequence similarities
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Contains 1 protein kinase domain.
Cellular localization
Membrane.
Target information above from: UniProt accessionQ16671
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- AMH type II receptor antibody
- AMHR2 antibody
- AMHR2_HUMAN antibody
see all
Database links
- Entrez Gene: 269 Human
- Omim: 600956 Human
- SwissProt: Q16671 Human
- Unigene: 659889 Human
Anti-AMHR2 antibody - Aminoterminal end images:
Western blot - AMHR2 antibody - Aminoterminal end (ab75845)
All lanes : Anti-AMHR2 antibody - Aminoterminal end (ab75845) at 1/50 dilution
Lane 1 : Non transfected 293 cell lysates
Lane 2 : Transiently transfected 293 cell lysates
Lysates/proteins at 2 µg per lane.
Predicted band size : 63 kDa
Observed band size : 63 kDa
References for Anti-AMHR2 antibody - Aminoterminal end (ab75845)
ab75845 has not yet been referenced specifically in any publications.
Publishing research using ab75845? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"