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Anti-AMHR2 antibody [MIG7] (ab64762)

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Overview

Product name

Anti-AMHR2 antibody [MIG7]
See all AMHR2 products (3) ...

Description

Mouse monoclonal [MIG7] to AMHR2

Specificity

Recognizes human cells bearing AMHR2 extracellular domain.

Tested applications

IHC-P, WB, Indirect ELISA, ICC/IFmore details

Cross reactivity

Reacts with

Rat, Human

Predicted to work with

Rabbit

Immunogen

Synthetic peptide: NANYSHLPPPGSPG, corresponding to amino acids 117-130 of Human AMHR2

NANYSHLPPP GSPG

Run BLAST with BLAST the sequence with ExPASyRun BLAST with BLAST the sequence with NCBI

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Storage buffer

Preservative: 0.1% Sodium Azide
Constituents: PBS, pH 7.4

Concentration

Concentration information loading...

Purity

Protein G purified

Clonality

Monoclonal

Clone number

MIG7

Myeloma

Sp2/0

Isotype

IgG1

Research areas

Stem Cells >> Signaling Pathways >> TGF beta >> Surface Molecules
Signal Transduction >> Growth Factors/Hormones >> TGF
Signal Transduction >> Protein Phosphorylation >> Ser / Thr Kinases >> Other Kinases

Applications

Show applications key

Our Abpromise guarantee covers the use of ab64762 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Target

Function

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.

Involvement in disease

Defects in AMHR2 are the cause of persistent Muellerian duct syndrome type 2 (PMDS2) [MIM:261550]. PMDS2 is a form of male pseudohermaphroditism characterized by a failure of Muellerian duct regression in otherwise normal males.

Sequence similarities

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Contains 1 protein kinase domain.

Cellular localization

Membrane.

Target information above from: UniProt accessionQ16671 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • AMH type II receptor antibody
  • AMHR2 antibody
  • AMHR2_HUMAN antibody
  • Anti-Muellerian hormone type II receptor antibody
  • Anti-Muellerian hormone type-2 receptor antibody
  • MGC141312 antibody
  • MIS type II receptor antibody
  • MISRII antibody
  • MRII antibody
  • Muellerian hormone type 2 receptor antibody
  • Muellerian hormone type II receptor antibody
  • Mullerian hormone receptor type II antibody
see all

Database links

References for Anti-AMHR2 antibody [MIG7] (ab64762)

This product has been referenced in:

  • Corbetta Set al. Gonadal structures in a fetus with complete androgen insensitivity syndrome and persistent Müllerian derivatives: comparison with normal fetal development. Fertil Steril 95:1119.e9-1119.e14 (2011). IHC-P; Human.Read more (PubMed: 20971460) »

See 1 publication for this product

Publishing research using ab64762? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"