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Products:Signal Transduction >> Metabolism >> Energy Metabolism
Overview
Product name
Anti-AMPD1 antibody
See all AMPD1 products (2) ...
Description
Rabbit polyclonal to AMPD1
Tested applications
WB, IHC-Pmore details
Cross reactivity
Reacts with
Mouse, Rat, Cow, Dog, Human, Monkey
Predicted to work with
Chimpanzee
Immunogen
Synthetic peptide corresponding to a region between residues 140 and 190 of human AMPD1 (NP_000027).
Positive control
Mouse and rat skeletal muscle lysates. Human skeletal muscle tissue.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
Preservative: 0.05% Sodium Azide
Constituents: 0.2% Gelatin, PBS
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Applications
Show applications key
Our Abpromise guarantee covers the use of ab72541 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use a concentration of 0.5 - 2 µg/ml.Detects a band of approximately 87 kDa (predicted molecular weight: 87 kDa).
IHC-P: Use a concentration of 10 µg/ml
Target
Relevance
AMP deaminase (AMPD) is an allosteric enzyme that plays a critical role in energy metabolism. There are three functional isoforms of AMPD. AMPD1 is the skeletal muscle-specific isoform M located in type II muscle fibers, neuromuscular junctions and in capillaries. Defects in AMPD1 are the cause of adenosine monophosphate deaminase deficiency muscle type (AMPDDM). AMPDDM is a metabolic disorder resulting in exercise-related myopathy. It is characterized by exercise-induced muscle aches, cramps, and early fatigue.
Alternative names
- Adenosine monophosphate deaminase 1 (isoform M) antibody
- Adenosine monophosphate deaminase 1 antibody
- AMP deaminase 1 antibody
see all
Database links
- Entrez Gene: 270 Human
- Entrez Gene: 229665 Mouse
- Entrez Gene: 25028 Rat
- Omim: 102770 Human
- SwissProt: P23109 Human
- SwissProt: Q3V1D3 Mouse
- SwissProt: P10759 Rat
Anti-AMPD1 antibody images:
Western blot - AMPD1 antibody (ab72541)
All lanes : Anti-AMPD1 antibody (ab72541) at 1 µg/ml
Lane 1 : Mouse skeletal muscle lysate
Lane 2 : Mouse skeletal muscle lysate with immunising peptide
Lane 3 : Rat skeletal muscle lysate
Predicted band size : 87 kDa
Observed band size : 87 kDa
Additional bands at : 10 kDa. We are unsure as to the identity of these extra bands.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - AMPD1 antibody (ab72541)
ab72541 at 10µg/ml staining AMPD1 in human skeletal muscle by Immunohistochemistry using paraffin-embedded tissue.
References for Anti-AMPD1 antibody (ab72541)
ab72541 has not yet been referenced specifically in any publications.
Publishing research using ab72541? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"