Loading...
You have changed your country from
to
. Please be aware that this will change the currency in the purchasing process.
Products:Signal Transduction >> Protein Phosphorylation >> Ser / Thr Kinases >> Other Kinases
Overview
Product name
Anti-AMPK alpha 2 antibody (Agarose)
See all AMPK alpha 2 products (10) ...
Description
Rabbit polyclonal to AMPK alpha 2 (Agarose)
Conjugation
Agarose
Tested applications
Cross reactivity
Reacts with
Rat, Cow, Human
Immunogen
Synthetic peptide, represented a portion of AMP activated protein kinase, alpha-2 catalytic subunit encoded within exon 7.
General notes
Affinity purified antibodies were coupled to agarose beads using a cyanogen bromide method. Antibody is supplied as 100ug coupled to 200ul agarose as a 50% slurry in 400ul volume, giving a final concentration of 0.25ug/ul in the slurry.
Properties
Form
Liquid
Storage instructions
Store at +4°C. Do not freeze.
Storage buffer
Preservative: 0.1% Sodium Azide
Constituents: 0.1M Sodium chloride, 0.01M PBS, pH 7.2
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Applications
Show applications key
Our Abpromise guarantee covers the use of ab19208 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IP
Application notes
IP: Use at a concentration of 15 - 25 µl of gel slurry/0.1 - 1 mg of protein lysate or extract.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Function
Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit.
Sequence similarities
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
Contains 1 protein kinase domain.
Target information above from: UniProt accessionP54646
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- 5' AMP activated protein kinase catalytic alpha 2 chain antibody
- 5' AMP activated protein kinase catalytic subunit alpha 2 antibody
- 5'-AMP-activated protein kinase catalytic subunit alpha-2 antibody
see all
Database links
- Entrez Gene: 5563 Human
- Entrez Gene: 78975 Rat
- Omim: 600497 Human
- SwissProt: P54646 Human
- SwissProt: Q09137 Rat
- Unigene: 256067 Human
- Unigene: 437039 Human
- Unigene: 64583 Rat
References for Anti-AMPK alpha 2 antibody (Agarose) (ab19208)
ab19208 has not yet been referenced specifically in any publications.
Publishing research using ab19208? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"