Anti-ANKRD1 antibody (ab64963)

Overview

• Product nameAnti-ANKRD1 antibodySee all ANKRD1 primary antibodies ...
• Description
  Rabbit polyclonal to ANKRD1
• SpecificityDetects endogenous levels of total ANKRD1 protein.
• Tested applicationsWB, ELISA more details
• Species reactivity
  Reacts with: Rat, Human
  Predicted to work with: Mouse
• Immunogen

  Synthetic peptide (Human) from an internal region

• Positive controlCOLO205 cell extract

Properties

• FormLiquid
• Storage instructionsStore at -20°C. Stable for 12 months at -20°C
• Storage bufferPreservative: 0.02% Sodium Azide
  Constituents: 50% Glycerol, PBS, 150mM Sodium chloride, pH 7.4
• Concentration information loading...
• PurityImmunogen affinity purified
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Cardiovascular
  • Heart
  • Cardiogenesis
  • Transcription factors/regulators

  • Epigenetics and Nuclear Signaling
  • Transcription
  • Other factors

Applications

Target

• FunctionMay play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes. Induction seems to be correlated with apoptotic cell death in hepatoma cells.
• Tissue specificityMainly expressed in activated vascular endothelial cells. To a lower extent, also expressed in hepatoma cells.
• Involvement in diseaseDefects in ANKRD1 may be a cause of total anomalous pulmonary venous return (TAPVR) [MIM:106700]. TAPVR is a rare congenital heart disease (CHD) in which the pulmonary veins fail to connect to the left atrium during cardiac development, draining instead into either the right atrium or one of its venous tributaries. This disease accounts for 1.5% of all CHDs and has a prevalence of approximately 1 out of 15'000 live births.
• Sequence similaritiesContains 5 ANK repeats.
• Cellular localizationNucleus.

Target information above from: UniProt accession Q15327 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 27063 Human
  • Entrez Gene: 107765 Mouse
  • Entrez Gene: 27064 Rat
  • Omim: 609599 Human
  • SwissProt: Q15327 Human
  • SwissProt: Q9CR42 Mouse
  • SwissProt: Q8R560 Rat
  • Unigene: 448589 Human

  • Unigene: 10279 Mouse
  • Unigene: 3789 Rat

  see all

• Alternative names
  ALRP antibodyANKR1_HUMAN antibodyANKRD 1 antibody

  ANKRD1 antibodyAnkyrin repeat domain 1 (cardiac muscle) antibodyAnkyrin repeat domain containing protein 1 antibodyAnkyrin repeat domain-containing protein 1 antibodybA320F15.2 antibodyC 193 antibodyC193 antibodyCardiac ankyrin repeat protein antibodyCARP antibodyCVARP antibodyCytokine inducible nuclear protein antibodyCytokine-inducible gene C-193 protein antibodyCytokine-inducible nuclear protein antibodyHA1A2 antibodyLiver ankyrin repeat domain 1 antibodyMCARP antibodyOTTHUMP00000020084 antibody

  see all

Anti-ANKRD1 antibody images

• 

  Western blot - ANKRD1 antibody (ab64963)
  All lanes : Anti-ANKRD1 antibody (ab64963) at 1/500 dilution
  
  Lane 1 : COLO205 cell extract
  Lane 2 : COLO205 cell extract with immunising peptide at 5 µg
  
  Lysates/proteins at 5 µg per lane.
  
  
  Predicted band size : 36 kDa
  Observed band size : 36 kDa