Anti-ANKS1B antibody (ab116083)

Overview

• Product nameAnti-ANKS1B antibodySee all ANKS1B primary antibodies ...
• Description
  Rabbit polyclonal to ANKS1B
• Tested applicationsWB more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  Synthetic peptide conjugated to KLH, corresponding to a region within internal sequence amino acids 569-599 of Human ANKS1B (NP_064525.1 , NP_858056.2 , NP_690001.3).

• Positive controlNCI-H292 cell line lysates.

Properties

• FormLiquid
• Storage instructionsStore at 4°C (up to 6 months). For long term storage store at -20°C
• Storage bufferPreservative: 0.09% Sodium azide
  Constituent: 99% PBS
• Concentration information loading...
• PurityImmunogen affinity purified
• Purification notes This antibody is purified through a protein A column, followed by peptide affinity purification.
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Neuroscience
  • Neurology process
  • Neurodegenerative disease
  • Alzheimer's disease
  • Other

  • Neuroscience
  • Neurology process
  • Neurodegenerative disease
  • Alzheimer's disease
  • Amyloid

Applications

Target

• FunctionIsoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells.
  Isoform 3 can regulate global protein synthesis by altering nucleolar numbers.
  Isoform 4 may play a role as a modulator of APP processing. Overexpression can down-regulate APP processing.
• Tissue specificityHighly expressed in marrow from patients with pre-B ALL associated with the t(1;19) translocation. Strongly expressed in brain and testis. Expressed in fetal brain. Isoform 4 is highly expressed in brain (at protein level). Isoform 6 is expressed in brain and several cancer cell lines.
• Sequence similaritiesContains 7 ANK repeats.
  Contains 1 PID domain.
  Contains 2 SAM (sterile alpha motif) domains.
• Post-translational
  modificationsIsoform 3 nuclear translocation requires an NMDAR-dependent proteolytic cleavage.
• Cellular localizationCytoplasm; Nucleus; Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. Cell projection > dendritic spine. Nucleus. Nucleus > Cajal body. The synaptic localization requires DLG4 interaction. Translocation to the nucleus in response to stimulation of NMDA receptors (NMDARs) in a calcium-independent manner and Nucleus. The interaction with APP causes its partial exclusion from the nucleus, when APP is overexpressed.

Target information above from: UniProt accession Q7Z6G8 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 56899 Human
  • Entrez Gene: 56899 Human
  • Omim: 607815 Human
  • SwissProt: Q7Z6G8 Human
  • SwissProt: Q7Z6G8 Human
  • Unigene: 506458 Human

• Alternative names
  AIDA antibodyAIDA-1 antibodyAmyloid-beta protein intracellular domain-associated protein 1 antibody

  Anks1b antibodyANKS2 antibodyAnkyrin repeat and sterile alpha motif domain containing 1B antibodyAnkyrin repeat and sterile alpha motif domain-containing protein 1B antibodyANS1B_HUMAN antibodyCajalin 2 antibodyE2A-PBX1-associated protein antibodyEB-1 antibodyEB1 antibodyMGC26087 antibody

  see all

Anti-ANKS1B antibody images

• 

  Western blot - Anti-ANKS1B antibody (ab116083)
  Anti-ANKS1B antibody (ab116083) at 1/100 dilution + NCI-H292 cell line lysates at 35 µg
  
  Predicted band size : 138 kDa