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Products:Cardiovascular >> Blood >> Other
Overview
Product name
Anti-ANP antibody [L11-11-D6-B4]
See all ANP products (13) ...
Description
Mouse monoclonal [L11-11-D6-B4] to ANP
Specificity
ab14442 recognizes synthetic ANP.
Tested applications
ELISAmore details
Cross reactivity
Reacts with
Human
Predicted to work with
Mouse, Rat, Sheep, Rabbit, Horse, Guinea pig, Cow, Cat, Dog, Pig
Immunogen
Poly Lysin conjugated synthetic peptide: SLRRSSCFGGRMDRFGAQSGLGCNSFRY, corresponding to amino acids 1-28 of Human ANP.
SLRRSSCFGG RMDRFGAQSG LGCNSFRY
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: 50mM Tris HCl. pH 7.4
Concentration
Concentration information loading...
Purity
Protein G purified
Purification notes
Cell culture supernatant, Protein G purified.
Clonality
Monoclonal
Clone number
L11-11-D6-B4
Isotype
IgG1
Research areas
Cardiovascular >> Heart >> Hypertrophy >> Other
Cardiovascular >> Heart >> Hypertrophy >> Hormones
Cardiovascular >> Blood >> Blood Pressure regulation
Signal Transduction >> Growth Factors/Hormones >> Hormones
Cardiovascular >> Blood >> Other
Applications
Show applications key
Our Abpromise guarantee covers the use of ab14442 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ELISA: Use at an assay dependent dilution.
Target
Function
Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilatation. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.
Involvement in disease
Defects in NPPA are the cause of atrial fibrillation familial type 6 (ATFB6) [MIM:612201]. Atrial fibrillation is a common disorder of cardiac rhythm that is hereditary in a small subgroup of patients. It is characterized by disorganized atrial electrical activity, progressive deterioration of atrial electromechanical function and ineffective pumping of blood into the ventricles. It can be associated with palpitations, syncope, thromboembolic stroke, and congestive heart failure.
Sequence similarities
Belongs to the natriuretic peptide family.
Post-translational
modifications
Cleaved by CORIN upon secretion to produce the functional hormone.
Cellular localization
Secreted.
Target information above from: UniProt accessionP01160
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- ANF antibody
- ANF_HUMAN antibody
- ANP antibody
see all
Database links
- Entrez Gene: 281355 Cow
- Entrez Gene: 608289 Dog
- Entrez Gene: 4878 Human
- Entrez Gene: 230899 Mouse
- Entrez Gene: 397496 Pig
- Entrez Gene: 24602 Rat
- Omim: 108780 Human
- SwissProt: Q9GLD0 Cat
see all
References for Anti-ANP antibody [L11-11-D6-B4] (ab14442)
This product has been referenced in:
- Bovill Eet al. Induction by left ventricular overload and left ventricular failure of the human Jumonji gene (JARID2) encoding a protein that regulates transcription and reexpression of a protective fetal program. J Thorac Cardiovasc Surg 136:709-16 (2008).Read more (PubMed: 18805276) »
See 1 publication for this product
Publishing research using ab14442? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"