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Products:Cardiovascular >> Blood >> Other
Overview
Product name
Anti-ANP antibody [M622709]
See all ANP products (13) ...
Description
Mouse monoclonal [M622709] to ANP
Specificity
Affinity Constant: 2.2 x 1010 L/M
Tested applications
Flow Cyt, RIA, IHC-Pmore details
Cross reactivity
Reacts with
Human
Immunogen
Atrial Natriuretic Peptide whole molecule
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.1% Sodium Azide
Constituents: PBS
Concentration
Concentration information loading...
Purity
Protein A purified
Clonality
Monoclonal
Clone number
M622709
Isotype
IgG1
Research areas
Cardiovascular >> Heart >> Hypertrophy >> Other
Cardiovascular >> Heart >> Hypertrophy >> Hormones
Cardiovascular >> Blood >> Blood Pressure regulation
Signal Transduction >> Growth Factors/Hormones >> Hormones
Cardiovascular >> Blood >> Other
Applications
Show applications key
Our Abpromise guarantee covers the use of ab2093 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Flow Cyt
RIA
IHC-P
Application notes
Flow Cyt: Use at an assay dependent dilution (PMID 20080656).
IHC-P: Use at an assay dependent dilution.
RIA: Use at an assay dependent dilution.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Function
Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilatation. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.
Involvement in disease
Defects in NPPA are the cause of atrial fibrillation familial type 6 (ATFB6) [MIM:612201]. Atrial fibrillation is a common disorder of cardiac rhythm that is hereditary in a small subgroup of patients. It is characterized by disorganized atrial electrical activity, progressive deterioration of atrial electromechanical function and ineffective pumping of blood into the ventricles. It can be associated with palpitations, syncope, thromboembolic stroke, and congestive heart failure.
Sequence similarities
Belongs to the natriuretic peptide family.
Post-translational
modifications
Cleaved by CORIN upon secretion to produce the functional hormone.
Cellular localization
Secreted.
Target information above from: UniProt accessionP01160
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- ANF antibody
- ANF_HUMAN antibody
- ANP antibody
see all
Database links
- Entrez Gene: 4878 Human
- Omim: 108780 Human
- SwissProt: P01160 Human
- Unigene: 75640 Human
References for Anti-ANP antibody [M622709] (ab2093)
This product has been referenced in:
- Therrien JPet al. A gene therapy approach for long-term normalization of blood pressure in hypertensive mice by ANP-secreting human skin grafts. Proc Natl Acad Sci U S A 107:1178-83 (2010). IHC-P, Flow Cyt; Human.Read more (PubMed: 20080656) »
See 1 publication for this product
Publishing research using ab2093? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"