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Products:Cardiovascular >> Blood >> Other

Anti-ANP antibody (ab14348)

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Overview

Product name

Anti-ANP antibody
See all ANP products (13) ...

Description

Rabbit polyclonal to ANP

Tested applications

ICC, ICC/IF, RIAmore details

Cross reactivity

Reacts with

Mouse, Rat

Predicted to work with

Guinea pig, Chimpanzee, Gorilla

Immunogen

Synthetic peptide: SLRRSSCFGGRIDRIGAQSGLGCNSFRY, corresponding to amino acids 1-28 of Rat ANP.

SLRRSSCFGG RIDRIGAQSG LGCNSFRY

Run BLAST with BLAST the sequence with ExPASyRun BLAST with BLAST the sequence with NCBI

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Storage buffer

Preservative: None
Constituents: Whole Serum

Purity

Whole antiserum

Clonality

Polyclonal

Isotype

IgG

Research areas

Cardiovascular >> Heart >> Hypertrophy >> Other
Cardiovascular >> Heart >> Hypertrophy >> Hormones
Cardiovascular >> Blood >> Blood Pressure regulation
Signal Transduction >> Growth Factors/Hormones >> Hormones
Cardiovascular >> Blood >> Other

Applications

Show applications key

Our Abpromise guarantee covers the use of ab14348 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Target

Function

Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilatation. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.

Involvement in disease

Defects in NPPA are the cause of atrial fibrillation familial type 6 (ATFB6) [MIM:612201]. Atrial fibrillation is a common disorder of cardiac rhythm that is hereditary in a small subgroup of patients. It is characterized by disorganized atrial electrical activity, progressive deterioration of atrial electromechanical function and ineffective pumping of blood into the ventricles. It can be associated with palpitations, syncope, thromboembolic stroke, and congestive heart failure.

Sequence similarities

Belongs to the natriuretic peptide family.

Post-translational
modifications

Cleaved by CORIN upon secretion to produce the functional hormone.

Cellular localization

Secreted.

Target information above from: UniProt accessionP01160 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • ANF antibody
  • ANF_HUMAN antibody
  • ANP antibody
  • ATFB6 antibody
  • Atrial natriuretic factor antibody
  • Atrial natriuretic factor precursor antibody
  • Atrial natriuretic peptide antibody
  • Atriopeptin antibody
  • Cardionatrin antibody
  • CDD ANF antibody
  • CDD-ANF antibody
  • CDP antibody
  • Natriuretic peptide A antibody
  • Natriuretic Peptide Precursor A antibody
  • NPPA antibody
  • PND antibody
  • Prepronatriodilatin antibody
see all

Database links

References for Anti-ANP antibody (ab14348)

This product has been referenced in:

  • Potokar Met al. Intermediate filaments attenuate stimulation-dependent mobility of endosomes/lysosomes in astrocytes. Glia 58:1208-19 (2010). ICC/IF; Mouse.Read more (PubMed: 20544856) »

See 1 publication for this product

Publishing research using ab14348? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"