Anti-ANP antibody (ab14354)

Overview

• Product nameAnti-ANP antibodySee all ANP primary antibodies ...
• Description
  Sheep polyclonal to ANP
• Tested applicationsELISA, RIA more details
• Species reactivity
  Reacts with: Human
  Predicted to work with: Mouse, Rat, Sheep, Rabbit, Horse, Guinea pig, Cow, Cat, Dog
• Immunogen

  Poly Lysin conjugated synthetic peptide: SLRRSSCFGGRMDRFGAQSGLGCNSFRY, corresponding to amino acids 1-28 of Human ANP.

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Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Storage bufferPreservative: None
  Constituents: Whole Serum
• PurityWhole antiserum
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Signal Transduction
  • Growth Factors/Hormones
  • Hormones

  • Cardiovascular
  • Blood
  • Blood Pressure regulation

  • Cardiovascular
  • Heart
  • Hypertrophy
  • Other

  • Cardiovascular
  • Heart
  • Hypertrophy
  • Hormones

  • Cardiovascular
  • Blood
  • Other

Applications

Target

• FunctionHormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilatation. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.
• Involvement in diseaseDefects in NPPA are the cause of atrial fibrillation familial type 6 (ATFB6) [MIM:612201]. Atrial fibrillation is a common disorder of cardiac rhythm that is hereditary in a small subgroup of patients. It is characterized by disorganized atrial electrical activity, progressive deterioration of atrial electromechanical function and ineffective pumping of blood into the ventricles. It can be associated with palpitations, syncope, thromboembolic stroke, and congestive heart failure.
• Sequence similaritiesBelongs to the natriuretic peptide family.
• Post-translational
  modificationsCleaved by CORIN upon secretion to produce the functional hormone.
• Cellular localizationSecreted.

Target information above from: UniProt accession P01160 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 281355 Cow
  • Entrez Gene: 608289 Dog
  • Entrez Gene: 4878 Human
  • Entrez Gene: 230899 Mouse
  • Entrez Gene: 24602 Rat
  • Omim: 108780 Human
  • SwissProt: Q9GLD0 Cat
  • SwissProt: P07501 Cow

  • SwissProt: P07499 Dog
  • SwissProt: P27104 Horse
  • SwissProt: P01160 Human
  • SwissProt: P05125 Mouse
  • SwissProt: P07500 Rabbit
  • SwissProt: P01161 Rat
  • SwissProt: O46540 Sheep
  • Unigene: 75640 Human

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• Alternative names
  ANF antibodyANF_HUMAN antibodyANP antibody

  ATFB6 antibodyAtrial natriuretic factor antibodyAtrial natriuretic factor precursor antibodyAtrial natriuretic peptide antibodyAtriopeptin antibodyCardionatrin antibodyCDD ANF antibodyCDD-ANF antibodyCDP antibodyNatriuretic peptide A antibodyNatriuretic Peptide Precursor A antibodyNPPA antibodyPND antibodyPrepronatriodilatin antibody

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